Prevalance of ACE Gene Polymorphism in Patients with End Stage Kidney Disease in Southeastern Turkey

Basit Öğe Kaydı
dc.contributor.authorZerman, Avar
dc.contributor.authorSit, Dede
dc.contributor.authorKadiroglu, Ali Kemal
dc.contributor.authorKayabasi, Hasan
dc.contributor.authorBudak, Metin
dc.contributor.authorYilmaz, Zi. Ilflikar
dc.contributor.authorYilmaz, M. Emin
dc.date.accessioned2024-04-24T17:40:45Z
dc.date.available2024-04-24T17:40:45Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: To evaluate the frequency of angiotensin converting enzyme gene polymorphism from renin angiotensin aidosterone system in patients undergoing chronic dialysis. Materials and Methods: Eighty-seven patients undergoing di;. alysis treatment and 38 healthy volunteers were enrolled in the study. Demographic features, arterial blood pressure, body mass index (BMI, hematological and biochemical parameters were recorded. ACE gene polymorphism was studied using sterile polymerase chain reaction (PCM method from blood samples taken into tubes containing EDTA. Results: Of the 87 patients, 49 were undergoing hemodialysis and 38 were on peritoneal dialysis programme. In the patient group male/female ratio was 48139 and the mean age was 41.11 +/- 13.6 years; in controls male/female ratio was 14,24 and the mean age was 38.0 +/- 1.41 years. Diabetes mellitus, hypertension, chronic glomerulonephritis were the first three causes of ESRD with percentages of 28, 24, and 23% respectively. Systolic and diastolic blood pressures were higher in patients than controls. ACE gene (I/D) polymorphism prevalence was found as 0.9%, 44.8%, 45.9% among patients. and 31.5%, 39.4%, 28.9% among controls for 11/D/DD respectively, and statistical significance was found (p=0.006). ACE D allele frequency was 68.4% among patients, and 48.7% among controls (p=0.001). Conclusion: We found difference in dispersion of ACE genotype and frequency of D allele between patients and controls.en_US
dc.identifier.endpage72en_US
dc.identifier.issn1300-7718
dc.identifier.issue2en_US
dc.identifier.startpage68en_US
dc.identifier.urihttps://hdl.handle.net/11468/21933
dc.identifier.volume16en_US
dc.identifier.wosWOS:000217153200006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isotren_US
dc.publisherTurk Nefroloji Diyaliz Transplantasyon Dergisien_US
dc.relation.ispartofTurkish Nephrology Dialysis and Transplantation Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEnd Stage Kidney Diseaseen_US
dc.subjectAce Gene Polymorphismen_US
dc.titlePrevalance of ACE Gene Polymorphism in Patients with End Stage Kidney Disease in Southeastern Turkeyen_US
dc.titlePrevalance of ACE Gene Polymorphism in Patients with End Stage Kidney Disease in Southeastern Turkey
dc.typeArticleen_US

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