Prevalance of ACE Gene Polymorphism in Patients with End Stage Kidney Disease in Southeastern Turkey
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Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turk Nefroloji Diyaliz Transplantasyon Dergisi
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: To evaluate the frequency of angiotensin converting enzyme gene polymorphism from renin angiotensin aidosterone system in patients undergoing chronic dialysis. Materials and Methods: Eighty-seven patients undergoing di;. alysis treatment and 38 healthy volunteers were enrolled in the study. Demographic features, arterial blood pressure, body mass index (BMI, hematological and biochemical parameters were recorded. ACE gene polymorphism was studied using sterile polymerase chain reaction (PCM method from blood samples taken into tubes containing EDTA. Results: Of the 87 patients, 49 were undergoing hemodialysis and 38 were on peritoneal dialysis programme. In the patient group male/female ratio was 48139 and the mean age was 41.11 +/- 13.6 years; in controls male/female ratio was 14,24 and the mean age was 38.0 +/- 1.41 years. Diabetes mellitus, hypertension, chronic glomerulonephritis were the first three causes of ESRD with percentages of 28, 24, and 23% respectively. Systolic and diastolic blood pressures were higher in patients than controls. ACE gene (I/D) polymorphism prevalence was found as 0.9%, 44.8%, 45.9% among patients. and 31.5%, 39.4%, 28.9% among controls for 11/D/DD respectively, and statistical significance was found (p=0.006). ACE D allele frequency was 68.4% among patients, and 48.7% among controls (p=0.001). Conclusion: We found difference in dispersion of ACE genotype and frequency of D allele between patients and controls.
Açıklama
Anahtar Kelimeler
End Stage Kidney Disease, Ace Gene Polymorphism
Kaynak
Turkish Nephrology Dialysis and Transplantation Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
16
Sayı
2
