The changes in Hoffbauer and syncytiotrophoblast cells in serious preeclampsia complicated with hellp syndrome (Ultrastructural and immunohistochemical study)

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dc.authorid0000-0002-9988-9385en_US
dc.authorid0000-0002-0166-9668en_US
dc.authorid0000-0002-6384-9146en_US
dc.authorid0000-0002-6384-9146en_US
dc.authorid0000-0002-6570-1057en_US
dc.authorid0000-0002-1680-907Xen_US
dc.authorid0000-0002-0549-8472en_US
dc.authorid0000-0002-1693-6378en_US
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorNergiz, Şebnem
dc.contributor.authorAşır, Fırat
dc.contributor.authorDeveci, Engin
dc.contributor.authorSak, Erdal
dc.contributor.authorEvsen, Sıddık
dc.contributor.authorTunik, Selçuk
dc.contributor.authorŞeker, Uğur
dc.date.accessioned2023-07-28T10:41:14Z
dc.date.available2023-07-28T10:41:14Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractHELLP syndrome is a syndrome characterized by hemolytic anemia, increased liver enzymes, and thrombopenia and can be seen in 1% of all pregnancies, 10-20% of pregnancies with pain, preeclampsia, and eclampsia. HELLP syndrome usually develops in the third trimester and its pathogenesis is not clear. Human placental villus stroma contains macrophages called Hoffbauer cells (HC), which are thought to be involved in many processes. HC is also called placental macrophage and has a role in many placental events. This study aimed to evaluate the immunohistochemistry and ultrastructural of syncytiotrophoblast and Hoffbauer cells in the placental villi of HELLP syndrome patients. In our study, placental tissues obtained from human normal and HELLP syndrome pregnancies were prepared for light and transmission electron microscopy (TEM) studies. Immunohistochemistry techniques were applied to placenta sections. HC localizations were determined with CD68 (Hoffbauer cell marker). Fine structure properties of HC and syncytiotrophoblasts were examined by TEM. When the HELLP group fetal placental sections were examined under the light microscope, intracytoplasmic edema in syncytiotrophoblast, degenerative vacuoles, and degenerative findings on cell surface membranes were observed. Moreover, villous edema was remarkable. The increase in the number of Hoffbauer cells per villus in the HELLP group was statistically significant (p<0.00). Compared with the control group, there was a significant increase in the number of Hoffbauer cells and syncytiotrophoblast in HELLP group, and also degenerative changes were observed in the ultrastructural structure of these cells.en_US
dc.identifier.citationNergiz, Y., Nergiz, Ş., Aşır, F., Deveci, E., Sak, E., Evsen, S. ve diğerleri. (2022). The changes in Hoffbauer and syncytiotrophoblast cells in serious preeclampsia complicated with hellp syndrome (Ultrastructural and immunohistochemical study). Middle East Journal of Science, 8(2), 91-98.en_US
dc.identifier.doi10.51477/mejs.1166842
dc.identifier.endpage98en_US
dc.identifier.issn2618-6136
dc.identifier.issue2en_US
dc.identifier.startpage91en_US
dc.identifier.trdizinid1147722
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1147722
dc.identifier.urihttps://hdl.handle.net/11468/12306
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1147722
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorNergiz, Yusuf
dc.institutionauthorNergiz, Şebnem
dc.institutionauthorAşır, Fırat
dc.institutionauthorDeveci, Engin
dc.institutionauthorSak, Erdal
dc.institutionauthorEvsen, Sıddık
dc.institutionauthorTunik, Selçuk
dc.institutionauthorŞeker, Uğur
dc.language.isoenen_US
dc.publisherINESEG Yayıncılıken_US
dc.relation.ispartofMiddle East Journal of Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHELLPen_US
dc.subjectHoffbauer cellen_US
dc.subjectSyncytiotrophoblasten_US
dc.subjectImmunohistochemistryen_US
dc.subjectPlacentaen_US
dc.titleThe changes in Hoffbauer and syncytiotrophoblast cells in serious preeclampsia complicated with hellp syndrome (Ultrastructural and immunohistochemical study)en_US
dc.titleThe changes in Hoffbauer and syncytiotrophoblast cells in serious preeclampsia complicated with hellp syndrome (Ultrastructural and immunohistochemical study)
dc.typeArticleen_US

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