Chemical characterization, anti-oxidant and anti-enzymatic properties of extracts from two Silene species: A focus on different plant parts and extraction methods

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dc.authorid0000-0001-6548-7823en_US
dc.authorid0000-0002-4675-2027en_US
dc.authorid0000-0002-4090-7227en_US
dc.contributor.authorAygün, Rabia Betül
dc.contributor.authorZengin, Gökhan
dc.contributor.authorYıldıztugay, Evren
dc.contributor.authorJugreet, Sharmeen
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorMahomoodally, Fawzi Mohamad
dc.date.accessioned2023-12-21T07:30:28Z
dc.date.available2023-12-21T07:30:28Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractIn this study, aerial part and root extracts of two Silene species, S. caramanica and S. otites obtained by five extraction methods (homogenizer assisted, maceration, Soxhlet, and ultrasound assisted extractions and infusion) were screened for their phytochemical contents, antioxidant and anti-enzymatic properties. Spectrophotometric assays revealed the extracts to possess total phenolic and flavonoid contents in the range of 13.28–47.18 mg gallic acid equivalent (GAE)/g dry extract and 0.22–42.56 mg rutin equivalent (RE)/g dry extract, respectively for S. caramanica and 13.97–21.35 mg GAE/g and 0.40–42.87 mg RE/g, respectively for S. otites. The aerial part extracts obtained by homogenizer assisted extraction of both plants were found to yield the highest phytochemical contents compared to the other extracts. HPLC analysis revealed quinic acid to be present in the highest quantity in the extracts. In DPPH and ABTS assays, the extracts demonstrated the highest free radical scavenging property (14.22–48.25 and 24.88–107.60 mg trolox equivalent (TE)/g dry extract, respectively), reducing activity in CUPRAC and FRAP assays (38.60–175.85 and 31.43–108.72 mg TE/g dry extract, respectively). While all extracts exhibited anti-acetylcholinesterase (0.69–2.56 mg galantamine equivalent (GALE)/g dry extract), anti-butyrylcholinesterase (0.80–2.50 mg GALE/g dry extract) activity displayed by only the aerial part/Soxhlet extract of S. caramanica, all root extracts of S. caramanica, and all the extracts of S. otites except their infusion extracts (0.80–2.50 mg GALAE/g dry extract). The extracts were also found to inhibit tyrosinase (2.36–20.95 mg kojic acid equivalent (KAE)/g dry extract), alpha-amylase (0.11–0.46 mmol acarbose equivalent (ACAE)/g dry extract), and with the exception of the root/infusion extracts, were also found to act as inhibitors of alpha-glucosidase (0.03–0.41 mmol ACAE/g dry extract). Taken together, this study revealed these two Silene species to act as antioxidants and enzyme inhibitors and the findings are in favor for more advanced studies to be carried out to confirm their pharmacological properties.en_US
dc.identifier.citationAygün, R. B., Zengin, G., Yıldıztugay, E., Jugreet, S., Yılmaz, M. A. ve Mahomoodally, F. M. (2022). Chemical characterization, anti-oxidant and anti-enzymatic properties of extracts from two Silene species: A focus on different plant parts and extraction methods. Process Biochemistry, 116, 206-213.en_US
dc.identifier.doi10.1016/j.procbio.2022.03.016
dc.identifier.endpage213en_US
dc.identifier.issn1359-5113
dc.identifier.scopus2-s2.0-85126831636
dc.identifier.scopusqualityQ1
dc.identifier.startpage206en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1359511322000988?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13105
dc.identifier.volume116en_US
dc.identifier.wosWOS:000806823100002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofProcess Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitionen_US
dc.subjectPhytochemicalsen_US
dc.subjectSilene caramanicaen_US
dc.subjectSilene otitesen_US
dc.titleChemical characterization, anti-oxidant and anti-enzymatic properties of extracts from two Silene species: A focus on different plant parts and extraction methodsen_US
dc.titleChemical characterization, anti-oxidant and anti-enzymatic properties of extracts from two Silene species: A focus on different plant parts and extraction methods
dc.typeArticleen_US

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