Carvacrol and pomegranate extract in treating methotrexate-induced lung oxidative injury in rats

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dc.contributor.authorŞen, Hadice Selimoǧlu
dc.contributor.authorŞen, Velat
dc.contributor.authorBozkurt, Mehtap
dc.contributor.authorTürkçü, Gül
dc.contributor.authorGüzel, Abdulmenap
dc.contributor.authorSezgi, Cengizhan
dc.contributor.authorAbakay, Özlem
dc.contributor.authorKaplan, İbrahim
dc.date.accessioned2024-04-24T17:56:36Z
dc.date.available2024-04-24T17:56:36Z
dc.date.issued2014
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: This study was designed to evaluate the effects of carvacrol (CRV) and pomegranate extract (PE) on methotrexate (MTX)-induced lung injury in rats.Material/Methods: A total of 32 male rats were subdivided into 4 groups: control (group I), MTX treated (group II), MTX+CRV treated (group III), and MTX+PE treated (group IV). A single dose of 73 mg/kg CRV was administered intraperitoneally to rats in group III on Day 1 of the investigation. To group IV, a dose of 225 mg/kg of PE was administered via orogastric gavage once daily over 7 days. A single dose of 20 mg/kg of MTX was given intraperitoneally to groups II, III, and IV on Day2. The total duration of experiment was 8 days. Malondialdehyde (MDA), total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) were measured from rat lung tissues and cardiac blood samples.Results: Serum and lung specimen analyses demonstrated that MDA, TOS, and OSI levels were significantly greater in group II relative to controls. Conversely, the TAC level was significantly reduced in group II when compared to the control group. Pre-administering either CRV or PE was associated with decreased MDA, TOS, and OSI levels and increased TAC levels compared to rats treated with MTX alone. Histopathological examination revealed that lung injury was less severe in group III and IV relative to group II.Conclusions: MTX treatment results in rat lung oxidative damage that is partially counteracted by pretreatment with either CRV or PE.en_US
dc.identifier.citationŞen, H. S., Şen, V., Bozkurt, M., Türkçü, G., Güzel, A., Sezgi, C. ve diğerleri. (2014). Carvacrol and pomegranate extract in treating methotrexate-induced lung oxidative injury in rats. Medical Science Monitor, 20, 1983-1990.
dc.identifier.doi10.12659/MSM.890972
dc.identifier.endpage1990en_US
dc.identifier.issn1234-1010
dc.identifier.pmid25326861
dc.identifier.scopus2-s2.0-84908121345
dc.identifier.scopusqualityQ1
dc.identifier.startpage1983en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.890972
dc.identifier.urihttps://hdl.handle.net/11468/23589
dc.identifier.volume20en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInternational Scientific Literature Inc.en_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMethotrexateen_US
dc.subjectOxidative stressen_US
dc.subjectPunicaceaeen_US
dc.titleCarvacrol and pomegranate extract in treating methotrexate-induced lung oxidative injury in ratsen_US
dc.titleCarvacrol and pomegranate extract in treating methotrexate-induced lung oxidative injury in rats
dc.typeArticleen_US

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