A potential species for cosmetic and pharmaceutical industries: Insight to chemical and biological investigation of naturally grown and cultivated Salvia multicaulis Vahl

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dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorYener, Ismail
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorKandemir, Sevgi Irtegun
dc.contributor.authorTekin, Fethullah
dc.contributor.authorErtas, Abdulselam
dc.date.accessioned2024-04-24T16:14:57Z
dc.date.available2024-04-24T16:14:57Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe importance of Salvia L. species, being used as traditional medicine, in the scientific world is increasing day by day. The relationship between health and traditional-modern life, promotes the creation of new value added food products. Within this context, in this study, it was aimed to biologically and chemically investigate the essential oil and ethanol extracts of the Salvia multicaulis Vahl. Chemical and biological study results of naturally grown and cultivated (uninvestigated in the literature) samples of S. multicaulis were compared. The essential oil, aroma and terpenoid-steroid contents of the species were determined by gas chromatography-mass spectrometry (GC-MS) and phenolic content by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). In addition, the bioactivities of the extracts were screened for antioxidant, cytotoxic, antialzheimer, antiurease, antityrosinase, antielastase and anticollagenase activities. It was found that the enzyme activities of the essential oil and the antioxidant activities of all ethanol extracts of the species were quite high. It was determined that especially essential oil and the ethanol extracts of the leaf parts exhibited high cytotoxic effect in cancer cell lines (PDF (Healthy primary dermal fibroblast cell line), HT-29 (colon cancer cell line), MCF-7 (breast cancer cell line), Caco-2 (colon cancer cell line) and Skov-3 (ovary cancer cell line)). According to the GC-MS results, in the natural specimen 1,8-cineole (33.05 %) and D-limonene (21.18 %), in the cultivated sample 1,8-cineole (42.35 %) and alpha-pinene (15.74 %) were detected to be as the major components of the essential oil and aroma, respectively. It was observed that both natural and cultivated samples were rich in beta-Sitosterol. Moreover, the root extract of natural samples was found to be richer than the other extracts in terms of abieatane diterpene (ferruginol, cryptanol, sugiol, and inuroyleanone) compounds. According to the LC-MS/MS results, it is seen that both natural and cultivated samples are very rich in rosmarinic acid. Especially, the flower part of the natural sample (98.10 mg analyte/g extract) was found to contain more rosmarinic acid than the other parts. Due to the high total phenolic and rosmarinic acid content, cytotoxic, anti-aging, and antioxidant potential of the ethanol extract of the leaf parts of the species, it has the potential to be used as a food supplement, food preservative and in the pharmaceutical industry.en_US
dc.description.sponsorshipDicle University [DUBTAM.19.001]en_US
dc.description.sponsorshipThe authors are thankful to Yeter Yesil and Dicle University Cancer Research Center for botanical identification and for MTT studies, respectively. This study was funded by Dicle University. Project number: DUBTAM.19.001.en_US
dc.identifier.doi10.1016/j.indcrop.2021.113566
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.scopus2-s2.0-85105260626
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.indcrop.2021.113566
dc.identifier.urihttps://hdl.handle.net/11468/15538
dc.identifier.volume168en_US
dc.identifier.wosWOS:000663436200004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofIndustrial Crops and Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSalvia Multicaulisen_US
dc.subjectCultivateden_US
dc.subjectEssential Oil And Terpenoid Contenten_US
dc.subjectBiological Activitiesen_US
dc.subjectAnti-Agingen_US
dc.titleA potential species for cosmetic and pharmaceutical industries: Insight to chemical and biological investigation of naturally grown and cultivated Salvia multicaulis Vahlen_US
dc.titleA potential species for cosmetic and pharmaceutical industries: Insight to chemical and biological investigation of naturally grown and cultivated Salvia multicaulis Vahl
dc.typeArticleen_US

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