Thymoquinone down-regulates VEGFA and Up-regulates FLT1 transcriptional levels in human breast cancer cells

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dc.authorid0000-0001-5518-5004en_US
dc.contributor.authorYegin, Z.
dc.contributor.authorDuran, T.
dc.contributor.authorYıldırım, İbrahim Halil
dc.date.accessioned2021-09-20T10:26:10Z
dc.date.available2021-09-20T10:26:10Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümü, Zootekn Ana Bilim Dalıen_US
dc.descriptionWOS:000525344900003
dc.description.abstractABSTRACT Angiogenesis is important for cancer progression index and angiogenesis factors related to tumorogenesis deserve to be investigated in detail. The use of minimally toxic phytochemical compounds as the new generation anticancer agents is an appreciated approach to manage angiogenesis factors. The purpose of this study was to investigate the potential effects of thymoquinone (TQ), the major constituent of the black seed, on the expression levels of VEGFA and its receptor FLT1 in human estrogen receptor-positive breast adenocarcinoma (MCF-7) cells. The researchers provide evidence that TQ down-regulated VEGFA and up-regulated FLT1 transcriptional levels in human breast cancer cells compared to HEK293 cells. To the best of the researchers’ knowledge, this is the first study determining the effect of TQ in VEGFA and its receptor FLT1 in MCF-cells and more comprehensive investigations are highly recommended.en_US
dc.identifier.citationYegin, Z., Duran, T. ve Yıldırım, I.H. (2020). Thymoquinone down-regulates VEGFA and Up-regulates FLT1 transcriptional levels in human breast cancer cells. International Journal of Human Genetics, 20(1), 19-24.en_US
dc.identifier.doi10.31901/24566330.2020/20.01.746
dc.identifier.endpage24en_US
dc.identifier.issn0972-3757
dc.identifier.issn2456-6330
dc.identifier.issue1en_US
dc.identifier.startpage19en_US
dc.identifier.urihttp://krepublishers.com/02-Journals/IJHG/IJHG-20-0-000-20-Web/IJHG-20-1-000-20-Abst-PDF/IJHG-20-01-019-20-746-Yegin-Z/IJHG-20-01-019-20-746-Yegin-Z-Tx[3].pdf
dc.identifier.urihttps://hdl.handle.net/11468/7720
dc.identifier.volume20en_US
dc.identifier.wosWOS:000525344900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorYıldırım, İbrahim Halil
dc.language.isoenen_US
dc.publisherKamla-Raj Enterprisesen_US
dc.relation.ispartofInternational Journal of Human Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectBreast tumoren_US
dc.subjectMCF-7 cellsen_US
dc.subjectThymoquinoneen_US
dc.subjectTranscriptionen_US
dc.titleThymoquinone down-regulates VEGFA and Up-regulates FLT1 transcriptional levels in human breast cancer cellsen_US
dc.titleThymoquinone down-regulates VEGFA and Up-regulates FLT1 transcriptional levels in human breast cancer cells
dc.typeArticleen_US

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