Is plasma concentration of NT-Pro-Brain natriuretic peptide associated with left ventricle hypertrophy among hemodialysis patients?

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dc.contributor.authorKadiroğlu, Ali Kemal
dc.contributor.authorŞit, Dede
dc.contributor.authorKayabaşı, Hasan
dc.contributor.authorKara, İsmail Hamdi
dc.contributor.authorYılmaz, M. Emin
dc.contributor.authorBatum, Sabri
dc.contributor.orcid0000-0003-2754-5687
dc.contributor.orcid0000-0003-1954-9784
dc.date.accessioned2024-04-24T15:59:23Z
dc.date.available2024-04-24T15:59:23Z
dc.date.issued2007
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: To determine the association of plasma amino terminal pro-brain natriuretic peptide (NT-proBNP) level with left ventricle hypertrophy (LVH) among hemodialysis (HD) patients. METHODS: We evaluated 65 patients on maintenance HD (28 women, 37 men) treated thrice weekly by low-flux hollow-fiber dialyzers for at least 6 months. Patients were divided into 2 groups according to whether they had LVH. NT-proBNP concentration of the patients was measured before and after the HD session. Cardiac parameters were detected by echocardiography after the day of HD after the session. RESULTS: In group 1 were the 34 patients who were LVH(-) (19 women and 15 men) and in group 2 were the 31 patients who were LVH(+) (9 women and 22 men). Mean left ventricular posterior wall diameter (LVPWd) was 0.87 +/- 0.16 cm in group 1 and 1.28 +/- 0.16 cm in group 2 (p < .001). Men were predominant in group 2 (p = .029). The patients in group 2 were older than those in group 1 (p = .033). There were no significant differences between the groups in pre-HD and post-HD NT-proBNP levels (p = .163 and p = .327, respectively). We did not find any significant relationship between mean concentration of pre-HD NT-proBNP and LVPWd (r = 0.064, p = 0.612). A positive correlation was found between mean concentration of pre-HD NT-proBNP with age (r = 0.281, p = 0.023), MAP (r = 0.469, p < 0.001), and left atrial diameter (r = 0.322, p = 0.009). CONCLUSION: Although increased serum levels of NT-proBNP in HD patients was found to be related to LAd, an indicator of hypervolemia, there was no association between NT-proBNP and LVH. Elevation of NT-proBNP is affected by multiple factors such as age, sex, arterial blood pressure, and dialyzer membrane.en_US
dc.identifier.citationKadiroğlu, A. K., Şit, D., Kayabaşı, H., Kara, İ. H., Yılmaz, M. E. ve Batum, S. (2007). Is plasma concentration of NT-Pro-brain natriuretic peptide associated with left ventricle hypertrophy among hemodialysis patients?. Dialysis and Transplantation, 36(6), 310-317.
dc.identifier.doi10.1002/dat.20130
dc.identifier.endpage315en_US
dc.identifier.issn0090-2934
dc.identifier.issn1932-6920
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-54849415114
dc.identifier.scopusqualityN/A
dc.identifier.startpage310en_US
dc.identifier.urihttps://doi.org/10.1002/dat.20130
dc.identifier.urihttps://hdl.handle.net/11468/14028
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/dat.20130
dc.identifier.volume36en_US
dc.identifier.wosWOS:000247120100003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDialysis & Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleIs plasma concentration of NT-Pro-Brain natriuretic peptide associated with left ventricle hypertrophy among hemodialysis patients?en_US
dc.titleIs plasma concentration of NT-Pro-Brain natriuretic peptide associated with left ventricle hypertrophy among hemodialysis patients?
dc.typeArticleen_US

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