Comparison of chemical and biological properties of in vivo and in vitro samples of Salvia siirtica Kahraman, Celep & Dogan extracts prepared with different solvents

Basit Öğe Kaydı
dc.contributor.authorFidan, Hilal Saruhan
dc.contributor.authorKilinc, Fatih Mehmet
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorYener, Ismail
dc.contributor.authorFirat, Mehmet
dc.contributor.authorOnay, Ahmet
dc.date.accessioned2024-04-24T16:18:20Z
dc.date.available2024-04-24T16:18:20Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe use of Salvia species among the public and their importance in the scientific world increase due to their numerous pharmacological and biological activities on a daily basis. In this study, the phytochemical contents of different parts (root, branch, leaf, flower, whole) of different specimens of Salvia siirtica (SS) (in vivo and in vitro) extracts prepared with various solvents (petroleumether, chloroformand ethanol) were determined using different techniques (GC-MS and LC-MS/MS) and the results were compared. In addition, biological activities (antioxidant, cytotoxic, anticholinesterase antiurease, antityrosinase, antielastase and anticollagenase) of all samples were determined and compared. The antioxidant potential of the analysed samples was found to be high, and their enzyme activity potential was low. Besides, in vitro SS-TIS (Temporary Immersion System) sample showed high cytotoxic activity (viability% 2.12 +/- 0.06) against MCF-7 (breast cancer) cell line. The results of GC-MS and LC-MS/MS analyses indicated that ferruginol and sugiol could be isolated from the ethanol extract of S. siirtica roots, salvigenin and beta-sitosterol from the chloroform extract of the aerial parts, and phenolic compounds from the ethanol extract of the aerial parts. In addition, the amount of rosmarinic acid, caffeic acid and 12-demethylmulticauline of in vitro samples were found to be higher than those of in vivo samples. Furthermore, all samples, both in vivo and in vitro, contained high levels of rosmarinic acid and beta-sitosterol. The whole chloroform extract (SSWC) could be the source extract for salvigenin (33952.13 mu g/g) and beta-sitosterol (16369.71 mu g/g), and the root ethanol extract (SSRE) for ferruginol (17721.99 mu g/g). As a result, it is understood that the nature of the plant material, the choice of an appropriate solvent and the parts of the material used are quite effective in chemical content. S. siirtica promise potential natural antioxidant agent in food and/or pharmaceutical industry due to its phytochemical content (rosmarinic and caffeic acids, ferruginol, salvigenin) and antioxidant activity. (C) 2021 Published by Elsevier B.V. on behalf of SAAB.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey) [KBAG 114Z801]en_US
dc.description.sponsorshipThis work was supported by TUBITAK (The Scientific and Technological Research Council of Turkey) (Project number: KBAG 114Z801).en_US
dc.identifier.doi10.1016/j.sajb.2021.07.029
dc.identifier.endpage429en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopus2-s2.0-85111207714
dc.identifier.scopusqualityQ1
dc.identifier.startpage421en_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2021.07.029
dc.identifier.urihttps://hdl.handle.net/11468/16007
dc.identifier.volume142en_US
dc.identifier.wosWOS:000701900700020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSouth African Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSalvia Siirticaen_US
dc.subjectIn Vitroen_US
dc.subjectIn Vivoen_US
dc.subjectSalvigeninen_US
dc.subjectFerruginolen_US
dc.subjectBiological Activitiesen_US
dc.titleComparison of chemical and biological properties of in vivo and in vitro samples of Salvia siirtica Kahraman, Celep & Dogan extracts prepared with different solventsen_US
dc.titleComparison of chemical and biological properties of in vivo and in vitro samples of Salvia siirtica Kahraman, Celep & Dogan extracts prepared with different solvents
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu