Polymorphism in the second intron of the FGFR2 gene rs1219648 associated with the early-onset breast cancer in Turkish population

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dc.contributor.authorTaskin, Irmak Icen
dc.contributor.authorTekin, Mehmet A.
dc.contributor.authorPektanc, Gulsum
dc.contributor.authorMunzuroglu, Omer
dc.contributor.authorKandemir, Sevgi Irtegun
dc.date.accessioned2024-04-24T17:37:47Z
dc.date.available2024-04-24T17:37:47Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe incidence of early-onset breast cancer has been increased up to 25% in the developing countries. Several studies reported that breast cancer cases in younger women have different biological characteristics than others. These patients should be studied separately. Lack of the necessary information about the younger patients prevents significant improvements about diagnosis and treatment strategies targeting these patients. Polymor-phisms within intron 2 of the FGFR2 gene have been associated with postmenopausal breast cancer patients in many populations. However, there exists no research on the impact of rs1219648 on early-onset breast cancer in Turkish population. In this study, the association of rs1219648 with early-onset breast cancer in Turkish women has been investigated. A total of 171 subjects, including 75 female breast cancer patients who were less than or equal to 40 years of age and 96 age-matched healthy controls were recruited. Our results indicate that G allele of the rs1219648 is statistically correlated with early-onset breast cancer (OR 2.0098, 95% CI 1.3016-3.1032, P=0.002). When rs1219648 was examined as a categorical variable where the reference category related to the wild-type genotype (AA), the calculated OR was [2.112 (95% CI 0.9904-4.5058), P= 0.053], and [5.2308 (95% CI 1.939114.1102), P=0.001], for genotypes AG and GG, respectively. We present the first report on FGFR2 rs1219648 polymorphism in early-onset breast cancer in Turkish women. Our results propose that rs1219648 polymorphism individually confers susceptibility for development of early-onset breast cancer in the Turkish populations.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Unit (FUBAP) [MF. 16.31]en_US
dc.description.sponsorshipThis work has been supported by Firat University Scientific Research Projects Unit (FUBAP) with project number MF. 16.31. The authors thank Mehmet Kucukoner and Huseyin Buyukbayram for their help to access to the information of patients.en_US
dc.identifier.endpage10994en_US
dc.identifier.issn1940-5901
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85025664069
dc.identifier.scopusqualityN/A
dc.identifier.startpage10989en_US
dc.identifier.urihttps://hdl.handle.net/11468/21177
dc.identifier.volume10en_US
dc.identifier.wosWOS:000406058200137
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRs1219648en_US
dc.subjectFgfr2 Geneen_US
dc.subjectEarly-Onset Breast Canceren_US
dc.subjectCancer Susceptibilityen_US
dc.subjectTurkish Womenen_US
dc.titlePolymorphism in the second intron of the FGFR2 gene rs1219648 associated with the early-onset breast cancer in Turkish populationen_US
dc.titlePolymorphism in the second intron of the FGFR2 gene rs1219648 associated with the early-onset breast cancer in Turkish population
dc.typeArticleen_US

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