Investigation of FAS and IL-6 Expression in Placentas with HELLP Syndrome

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dc.contributor.authorOtcu, Serap
dc.contributor.authorAtic, Esra Nur
dc.contributor.authorYavuz, Dilek
dc.date.accessioned2024-04-24T17:37:34Z
dc.date.available2024-04-24T17:37:34Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of our study was to investigate the effect of inflammation in the placenta on the pro-apoptotic development after severe preeclampsia. Placenta tissue samples of 15 HELLP syndrome and 15 healthy 35-38th week-pregnant women were involved in the study. Tissue samples were taken only from the maternal side of the placenta and fixed in 10 % formaldehyde, then blocked in paraffin wax and 4-6 mm-thick sections were cut and stained with Harris Hematoxylcne-Eosin. Antigen retrieval was performed for sections, incubated with FAS antibody and anti-IL-6 antibody. After the application of streptavidin peroxidase followed by AEC chromogen solution, sections were cotmterstained with I laths hematoxylin. Significant thickening of the fibrinoid layer, degeneration and apoptotic change in decidua cells, marked increase in the hyalinized area, degenerative changes in the syncytial regions of the chorionic villus and an increase in syncytial nodes and bridges and IL- expression were observed as positive. FAS expression was positive in the pycnotic nuclei of decidual cells in the maternal region and in the syncytial regions. It was observed that the proapoptotic process increased as a result of severe preeclampsia. It was concluded that the control of cytokine activity and reduction of pro-apoptotic signal during the inflammation process will slow down the development of HELLP syndrome.en_US
dc.identifier.endpage1235en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85141738860
dc.identifier.scopusqualityQ3
dc.identifier.startpage1228en_US
dc.identifier.urihttps://hdl.handle.net/11468/21031
dc.identifier.volume40en_US
dc.identifier.wosWOS:000893106700011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHellp Syndromeen_US
dc.subjectFas Expressionen_US
dc.subjectIl-6 Expressionen_US
dc.subjectPlacentaen_US
dc.titleInvestigation of FAS and IL-6 Expression in Placentas with HELLP Syndromeen_US
dc.titleInvestigation of FAS and IL-6 Expression in Placentas with HELLP Syndrome
dc.typeArticleen_US

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