Laminin receptor 1 expression in premalignant and malignant squamous lesions of the cervix

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dc.authoridKurdoglu, Mertihan/0000-0002-5344-9739
dc.authoridErten, Remzi/0000-0001-7775-5792
dc.contributor.authorKurdoglu, Mertihan
dc.contributor.authorKurdoglu, Zehra
dc.contributor.authorKucukaydin, Zehra
dc.contributor.authorErten, Remzi
dc.contributor.authorBulut, Guelay
dc.contributor.authorOzen, Suleyman
dc.date.accessioned2025-02-22T14:08:56Z
dc.date.available2025-02-22T14:08:56Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractLaminin receptor 1 (LAMR) may have a role in the progression of premalignant squamous epithelial lesions to cervical cancer. Therefore, we aimed to investigate the expression of laminin receptor 1 (LAMR) in normal, premalignant, and malignant tissues of the uterine cervix. Paraffin blocks of 129 specimens with the diagnoses of normal cervical tissue (n = 33), cervical intraepithelial neoplasia (CIN) 1 (n = 30), CIN 2 (n = 14), CIN 3 (n = 28), and squamous cell carcinoma (n = 24) were immunohistochemically stained with LAMR antibody and its expression percentage, pattern, and intensity in these tissues were assessed. Compared to the other groups, the nonstaining with LAMR was highest in low grade squamous intraepithelial lesion (LSIL) (p < 0.0001). LAMR expression, which was positive in less than 50% of cells with weak staining, increased significantly between normal cervical epithelium and high-grade squamous intraepithelial lesion (HSIL) or invasive carcinoma, as well as between LSIL and HSIL (p < 0.0001). Between LSIL and invasive carcinoma, a significant increment was also observed for weak staining in less than 50% of cells (p < 0.001). LAMR expression, which was positive in more than 50% of cells with strong staining, was significantly higher in normal cervical tissue compared to the other groups (p < 0.0001). Disease progression related gradual increment of LAMR expression from normal cervical epithelium or LSIL towards HSIL or cervical cancer reveals that LAMR may play an important role in the transition from premalignant to malignant state in cervical lesions.en_US
dc.identifier.doi10.1080/10520295.2024.2346912
dc.identifier.endpage181en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid38736402en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage174en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2024.2346912
dc.identifier.urihttps://hdl.handle.net/11468/29719
dc.identifier.volume99en_US
dc.identifier.wosWOS:001221997600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectCervix uterien_US
dc.subjecthigh-grade squamous intraepithelial lesionen_US
dc.subjectimmunohistochemistryen_US
dc.subjectlaminin receptor 1en_US
dc.subjectlow grade squamous intraepithelial lesionen_US
dc.subjectsquamous cell carcinomaen_US
dc.titleLaminin receptor 1 expression in premalignant and malignant squamous lesions of the cervixen_US
dc.typeArticleen_US

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