Effects of methanolic extract of Verbascum inulifolium Hub.-Mor. on incisional and excisional skin wounds in diabetic and non-diabetic rats

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dc.contributor.authorOzay, Yusuf
dc.contributor.authorGuzel, Sevda
dc.contributor.authorOzkorkmaz, Ebru Gokalp
dc.contributor.authorYildiz, Atilla
dc.contributor.authorYildirim, Zuhal
dc.contributor.authorErdogdu, Ibrahim Halil
dc.contributor.authorDarcan, Sinan
dc.date.accessioned2024-04-24T17:49:55Z
dc.date.available2024-04-24T17:49:55Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe genus Verbascum, commonly known as mullein, traditionally used in folk medicine, is known for its anti-inflammatory, antioxidant and antibacterial activities. Verbascum inulifolium Hub.-Mor. (Scrophulariaceae), is an endemic species from Turkey. Here, we examined the healing effect of methanol extract of the aerial parts of V. inulifolium on incisional and excisional skin wounds in diabetic and non-diabetic rats. Ointments of the extract were prepared in two concentrations (0.5 and 1% (w/w)) and applied topically on wound models once daily throughout for 7 and 14 days. During the experiments, wounds were visually observed, photographically documented and wound areas were measured. After 7 and 14 days treatments, animals were sacrificed and measurements of hydroxyproline level and biomechanical analysis were performed. Histopathology of the wound area was evaluated considering features of re-epithelialization, the granulation tissue thickness, angiogenesis, presence of inflammation, number of mast cells. Outcomes of this study revealed that the ethanolic extract of the aerial parts of V. inulifolium enhances the healing process of skin tissue in both non-diabetic and diabetic wounds. The best wound healing activity was observed in incisional wound treated with 0.5% (w/w) concentrated ointment (99.7%) and in excisional wound treated with 1% (w/w) concentrated ointment (98.1%) on day 14 according to macroscopic results.en_US
dc.description.sponsorshipAhi Evran University Department of Research Projects [PYO-SAG.4001.12.002]en_US
dc.description.sponsorshipThis study was supported by Ahi Evran University Department of Research Projects under the grant number PYO-SAG.4001.12.002.en_US
dc.identifier.endpage167en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue3en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://hdl.handle.net/11468/23093
dc.identifier.volume57en_US
dc.identifier.wosWOS:000462097200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal of Experimental Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectMulleinen_US
dc.subjectRe-Epithelializationen_US
dc.subjectVelvet Planten_US
dc.subjectWound Healingen_US
dc.titleEffects of methanolic extract of Verbascum inulifolium Hub.-Mor. on incisional and excisional skin wounds in diabetic and non-diabetic ratsen_US
dc.titleEffects of methanolic extract of Verbascum inulifolium Hub.-Mor. on incisional and excisional skin wounds in diabetic and non-diabetic rats
dc.typeArticleen_US

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