Effects of methanolic extract of Verbascum inulifolium Hub.-Mor. on incisional and excisional skin wounds in diabetic and non-diabetic rats
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Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Natl Inst Science Communication-Niscair
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The genus Verbascum, commonly known as mullein, traditionally used in folk medicine, is known for its anti-inflammatory, antioxidant and antibacterial activities. Verbascum inulifolium Hub.-Mor. (Scrophulariaceae), is an endemic species from Turkey. Here, we examined the healing effect of methanol extract of the aerial parts of V. inulifolium on incisional and excisional skin wounds in diabetic and non-diabetic rats. Ointments of the extract were prepared in two concentrations (0.5 and 1% (w/w)) and applied topically on wound models once daily throughout for 7 and 14 days. During the experiments, wounds were visually observed, photographically documented and wound areas were measured. After 7 and 14 days treatments, animals were sacrificed and measurements of hydroxyproline level and biomechanical analysis were performed. Histopathology of the wound area was evaluated considering features of re-epithelialization, the granulation tissue thickness, angiogenesis, presence of inflammation, number of mast cells. Outcomes of this study revealed that the ethanolic extract of the aerial parts of V. inulifolium enhances the healing process of skin tissue in both non-diabetic and diabetic wounds. The best wound healing activity was observed in incisional wound treated with 0.5% (w/w) concentrated ointment (99.7%) and in excisional wound treated with 1% (w/w) concentrated ointment (98.1%) on day 14 according to macroscopic results.
Açıklama
Anahtar Kelimeler
Diabetes Mellitus, Mullein, Re-Epithelialization, Velvet Plant, Wound Healing
Kaynak
Indian Journal of Experimental Biology
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
57
Sayı
3
