Can paricalcitol increase the effectiveness of N-acetylcysteine in contrast induced acute kidney prophylaxis in rats? A biochemical and histopathological study

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dc.authorid0000-0001-5424-5714en_US
dc.authorid0000-0001-7657-3065en_US
dc.authorid0000-0002-8101-2497en_US
dc.authorid0000-0002-1331-2906en_US
dc.authorid0000-0003-2813-1064en_US
dc.authorid0000-0001-7317-5467en_US
dc.authorid0000-0002-7768-2455en_US
dc.contributor.authorYıldırım, Yaşar
dc.contributor.authorBahadır, Veysi
dc.contributor.authorAydın, Emre
dc.contributor.authorAydın, Fatma Yılmaz
dc.contributor.authorYılmaz, Zülfükar
dc.contributor.authorKetani, Aydın
dc.contributor.authorKaplan, İbrahim
dc.contributor.authorTuncer, Mehmet Cudi
dc.contributor.authorKadiroǧlu, Ali Kemal
dc.contributor.authorYılmaz, Mehmet Emin
dc.date.accessioned2024-03-19T13:00:32Z
dc.date.available2024-03-19T13:00:32Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractN-Acetylcysteine (NAC) is used for contrast induced acut kidney injury (CI-AKI) prophylaxis because of its antioxidant effects. Paricalcitol, which has reno-protective effects, is likely to provide a more effective prophylaxis when added to NAC treatment. The study was designed based on this hypothesis. The study was organised to include 4 groups each consisting of 7 rats. Group 1 was the control group, and Group 2 included rats with CI-AKI. Rats in Group 3 were administered NAC at a dose of 100 mg/kg via oral gavage once a day for 5 days. Rats in group 4 were administered paricalcitol at a dose of 0.4 mcg/kg once a day for 5 days in addition to NAC. CI-AKI was induced after the treatments in both groups. The study was terminated on the sixth day. Samples were collected from the rats’ sera and kidney tissues to study oxidant and antioxidant parameters; kidney function tests were also studied. There were significant differences between the contrast nephropathy group (Group 2) and NAC and NAC+paricalcitol groups with respect to serum urea and creatinine levels. When the same groups were compared regarding oxidant (TOS-MDA) and antioxidant (TAC-Paraoxonase) parameters, we observed that the oxidant parameters increased in serum and kidney tissue samples with NAC use, and that effect was strengthened by the addition of paricalcitol to NAC treatment. However, despite increased antioxidant effectiveness, we observed no decrease in urea and creatinine levels when paricalcitol was added for CI-AKI in rats. There was no significant difference between Group 3 and Group 4. Paricalcitol provides a more potent antioxidant effect in both serum and kidney tissue samples when added to NAC treatment in rats with CI-AKI. Despite increased antioxidant parameters, however, paricalcitol does not provide a significant decrease in urea and creatinine levels.en_US
dc.identifier.citationYıldırım, Y., Bahadir, V., Aydın, E., Aydın, F. Y., Yılmaz, Z., Ketani, A. ve diğerleri. (2022). Can paricalcitol increase the effectiveness of N-acetylcysteine in contrast induced acute kidney prophylaxis in rats? A biochemical and histopathological study. International Journal of Morphology, 40(4), 1060-1066.en_US
dc.identifier.doi10.4067/S0717-95022022000401060
dc.identifier.endpage1066en_US
dc.identifier.issn0717-9367
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85139201107
dc.identifier.scopusqualityQ3
dc.identifier.startpage1060en_US
dc.identifier.urihttps://www.scielo.cl/pdf/ijmorphol/v40n4/0717-9502-ijmorphol-40-04-1060.pdf
dc.identifier.urihttps://hdl.handle.net/11468/13642
dc.identifier.volume40en_US
dc.identifier.wosWoSIDEksik
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYıldırım, Yaşar
dc.institutionauthorBahadır, Veysi
dc.institutionauthorAydın, Emre
dc.institutionauthorAydın, Fatma Yılmaz
dc.institutionauthorYılmaz, Zülfükar
dc.institutionauthorKetani, Aydın
dc.institutionauthorTuncer, Mehmet Cudi
dc.institutionauthorKadiroğlu, Ali Kemal
dc.institutionauthorYılmaz, Mehmet Emin
dc.institutionauthorKaplan, İbrahim
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectCI-AKIen_US
dc.subjectNACen_US
dc.subjectOxidative stressen_US
dc.subjectParicalcitolen_US
dc.titleCan paricalcitol increase the effectiveness of N-acetylcysteine in contrast induced acute kidney prophylaxis in rats? A biochemical and histopathological studyen_US
dc.titleCan paricalcitol increase the effectiveness of N-acetylcysteine in contrast induced acute kidney prophylaxis in rats? A biochemical and histopathological study
dc.title.alternative¿Puede el Paricalcitol Aumentar la Eficacia de la N-acetilcisteína en la Profilaxis Renal Aguda Inducida por Contraste en Ratas? Un Estudio Bioquímico e Histopatológicoen_US
dc.title.alternative¿Puede el Paricalcitol Aumentar la Eficacia de la N-acetilcisteína en la Profilaxis Renal Aguda Inducida por Contraste en Ratas? Un Estudio Bioquímico e Histopatológico
dc.typeArticleen_US

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