Investigation of autoantibody, anti-HCV and anti-HIV seropositivities in "anti-HBc alone" positive samples

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dc.contributor.authorMeşe S.
dc.contributor.authorÖzekinci T.
dc.contributor.authorYilmaz Ş.
dc.contributor.authorAtmaca S.
dc.contributor.authorArikan E.
dc.date.accessioned2024-04-24T18:43:39Z
dc.date.available2024-04-24T18:43:39Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstract"Anti-HBc alone" which is an unusual serologic pattern of hepatitis B virus (HBV) infections, may be detected in the seropositive samples for hepatitis C virus (HCV), human immunodeficiency virus (HIV) infections and in the presence of autoantibodies due to cross reactions. In this study, 20 serum samples with isolated antibody to hepatitis B core antigen, which were detected in May 2005, have been investigated by means of the presence of some autoantibodies (anti-nuclear antibody; ANA and rheumatoid factor; RF), anti-HCV and anti-HIV, in the Central Laboratory of Dicle University Medical School. All of the "anti-HBc alone" samples were negative for HBV-DNA by real-time polymerase chain reaction (PCR), and liver enzyme (ALT and AST) levels were normal except for three patients. As a result, a total of six (30%) samples were found positive. Four of them were positive for ANA and two were positive for anti-HCV, while one serum yielded positivity for both ANA and anti-HCV. Anti-HCV positive samples were searched for the presence of HCV-RNA by real-time PCR, and none were found positive. Of three patients with increased AST and ALT levels, one was anti-HCV positive, one was ANA positive, while the other was negative for all parameters. In conclusion, possible presence of autoantibodies and anti-HCV should be taken into consideration during the evaluation of isolated anti-HBc IgG positive test results.en_US
dc.identifier.endpage274en_US
dc.identifier.issn0374-9096
dc.identifier.issue3en_US
dc.identifier.pmid17001858en_US
dc.identifier.scopus2-s2.0-39049192353en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage269en_US
dc.identifier.urihttps://hdl.handle.net/11468/24259
dc.identifier.volume40en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isotren_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Hbc Aloneen_US
dc.subjectAnti-Hcven_US
dc.subjectAutoantibodyen_US
dc.subjectCross Reactionen_US
dc.titleInvestigation of autoantibody, anti-HCV and anti-HIV seropositivities in "anti-HBc alone" positive samplesen_US
dc.title.alternativeSalt anti-HBc pozitif örneklerde otoantikor, anti-HCV ve anti-HIV seropozitifliğinin araşt?r?lmas?en_US
dc.typeArticleen_US

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