Evaluation of ethanol extract of Morus nigra L. as an inhibitory agent for DNA-Advanced glycation end product (DNA-AGEs)

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dc.authorid0000-0002-9578-3786en_US
dc.authorid0000-0001-9603-0631en_US
dc.contributor.authorAkay, Feryal
dc.contributor.authorToptancı, Bircan Çeken
dc.contributor.authorİnceören, Nesrin
dc.contributor.authorKızıl, Göksel
dc.contributor.authorKızıl, Murat
dc.date.accessioned2024-04-17T11:23:15Z
dc.date.available2024-04-17T11:23:15Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractIn the developing countries there is a direct correlation between the amount of consumed foods containing starch and the increase in metabolic diseases. In contrast to glucose, fructose cannot be detected in the blood by insulin. Thus, it participates in lipogenesis and increases intracellular lipid accumulation.Reducing sugars results in the development of AGEs (Advanced Glycation End-Compounds) in biological macromolecules as well as some reactive products. These products can cause tissue damage by accumulating in the pathogenesis of a number of diseases by various mechanisms.AGEs can damage antioxidant systems by increasing ROS (reactive oxygen species). In this study, pBR322 DNA was incubated with different concentrations of fructose for 5 days. Damage to the structural system of fructosylated DNA was detected by an increase in fluorescence intensity and hyperchromicity. For five days, fructosylated DNA was treated with varying quantities of Morus nigra L. soxhlet extract and quercetin, and its impact on DNA structural damage was noted. The reduction in hyperchromicity and fluorescence intensity revealed the protective impact of quercetin and M. nigra L. extract on DNA. It has been found that the extract of M. nigra L. and quercetin both scavenge free radicals and reduce fructose-induced DNA damage.en_US
dc.description.sponsorshipDicle University FEN.17.031en_US
dc.identifier.citationAkay, F., Toptancı, B. Ç., İnceören, N., Kızıl, G. ve Kızıl, M. (2024). Evaluation of ethanol extract of Morus nigra L. as an inhibitory agent for DNA-Advanced glycation end product (DNA-AGEs). Indian Journal of Biochemistry and Biophysics, 61(2), 75-84.en_US
dc.identifier.doi10.56042/ijbb.v61i2.1610
dc.identifier.endpage84en_US
dc.identifier.issn0301-1208
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85185683897
dc.identifier.scopusqualityQ3
dc.identifier.startpage75en_US
dc.identifier.urihttps://or.niscpr.res.in/index.php/IJBB/article/view/1610/2462
dc.identifier.urihttps://hdl.handle.net/11468/13908
dc.identifier.volume61en_US
dc.identifier.wosWOS:001167040600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAkay, Feryal
dc.institutionauthorToptancı, Bircan Çeken
dc.institutionauthorİnceören, Nesrin
dc.institutionauthorKızıl, Göksel
dc.institutionauthorKızıl, Murat
dc.language.isoenen_US
dc.publisherNational Institute of Science Communication and Policy Researchen_US
dc.relation.ispartofIndian Journal of Biochemistry and Biophysics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDNA fructosylationen_US
dc.subjectDNA oxidationen_US
dc.subjectDNA-AGEsen_US
dc.subjectMorus nigra L.en_US
dc.subjectReactive oxygen speciesen_US
dc.titleEvaluation of ethanol extract of Morus nigra L. as an inhibitory agent for DNA-Advanced glycation end product (DNA-AGEs)en_US
dc.titleEvaluation of ethanol extract of Morus nigra L. as an inhibitory agent for DNA-Advanced glycation end product (DNA-AGEs)
dc.typeArticleen_US

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