Elevated serum ubiquitin-proteasome pathway related molecule levels in attention deficit hyperactivity disorder

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dc.contributor.authorCetin, Ihsan
dc.contributor.authorBulut, Hamdullah
dc.contributor.authorSimsek, Seref
dc.date.accessioned2024-04-24T17:18:01Z
dc.date.available2024-04-24T17:18:01Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: We aimed to determine the serum levels of transactive response of DNA-binding protein 43 (TDP-43) and ubiquitin C-terminal hydrolase-L1 (UCH-L1), which are ubiquitin-proteasome pathway related molecules and have not been investigated so far, in children with attention-deficit/hyperactivity disorder (ADHD). Methods: The study group was composed of thirty children aged between 6 and 10. They were diagnosed with ADHD according to DSM-IV criteria. They were the subjects who applied to Dicle University, Faculty of Medicine, and Department of Child Psychiatry in Diyarbakir, Turkey. Children with ADHD were assessed via Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale and Stroop test. Serum TDP-43 and UCH-L1 levels were analysed with enzyme-linked immuno-sorbent assay. Results: The TDP-43 and UCH-L1 serum levels of children with ADHD were found to be statistically significantly higher than those of controls. On the other hand, we found that serum levels of TDP-43 correlated with interference effect and hyperactivity-impulsivity in children with ADHD. Conclusion: Imbalances in serum UCH-L1 and TDP-43 levels, and the correlation of TDP-43 levels with clinical parameters in children with ADHD may suggest that ubiquitin--proteasome pathway alterations are associated with ADHD. Deterioration of this pathway may cause intracellular TDP-43 aggregation.en_US
dc.description.sponsorshipBatman University Scientific Research Project Unit [BTUBAP-2015-YL3]en_US
dc.description.sponsorshipWe thank the Batman University Scientific Research Project Unit for their support (BTUBAP-2015-YL3).en_US
dc.identifier.doi10.1515/tjb-2016-0291
dc.identifier.endpage193en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85020465653
dc.identifier.scopusqualityQ3
dc.identifier.startpage187en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2016-0291
dc.identifier.urihttps://hdl.handle.net/11468/18548
dc.identifier.volume42en_US
dc.identifier.wosWOS:000405114700009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdhden_US
dc.subjectTdp-43en_US
dc.subjectUch-L1en_US
dc.subjectNeurodegenerationen_US
dc.subjectUbiquitinationen_US
dc.titleElevated serum ubiquitin-proteasome pathway related molecule levels in attention deficit hyperactivity disorderen_US
dc.titleElevated serum ubiquitin-proteasome pathway related molecule levels in attention deficit hyperactivity disorder
dc.typeArticleen_US

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