Application of continuous wavelet transforms for simultaneous estimation of domperidone and lansoprazole in capsule formulations

Basit Öğe Kaydı
dc.authorid0000-0003-1537-1050en_US
dc.contributor.authorErtekin, Zehra Ceren
dc.contributor.authorBüker, Eda
dc.contributor.authorOral, Elif Varhan
dc.contributor.authorDinç, Erdal
dc.date.accessioned2025-02-20T11:27:47Z
dc.date.available2025-02-20T11:27:47Z
dc.date.issued2025en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractUV–Vis spectroscopy remains essential in pharmaceutical research and quality control due to its accessibility, simplicity, and effectiveness. However, overlapping spectra resulting from multicomponent drug formulations present challenges. Here, we describe a signal processing strategy using continuous wavelet transform (CWT) to resolve overlapping spectra of domperidone (DMP) and lansoprazole (LSP) for simultaneous quantification. Three different wavelet functions (Symlets 3, Coiflets 1, Daubechies 10), were found to be suitable for this purpose. Linear calibration curves were constructed using the CWT zero-crossing technique and the methods were validated by analyzing a set of synthetic mixtures, intra-and inter-day samples, and standard addition samples. The assay results of commercial capsule samples were compared with those obtained by derivative spectroscopy, and no significant statistical difference was observed. The proposed CWT methods demonstrated good compliance with the label claims and proved to be reliable, versatile, fast, and cost-efficient analytical methods without the need for preliminary separation procedures.en_US
dc.description.sponsorshipChemometrics Laboratory of Ankara University Faculty of Pharmacy 10A3336001en_US
dc.identifier.citationErtekin, Z. C., Büker, E., Oral, E. V. ve Dinç, E. (2025). Application of continuous wavelet transforms for simultaneous estimation of domperidone and lansoprazole in capsule formulations. Measurement: Journal of the International Measurement Confederation, 242, 1-10.en_US
dc.identifier.endpage10en_US
dc.identifier.issn0263-2241
dc.identifier.scopus2-s2.0-85209933788
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0263224124021729?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/29475
dc.identifier.volume242en_US
dc.identifier.wosWOS:001366011000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorOral, Elif Varhan
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofMeasurement: Journal of the International Measurement Confederation
dc.relation.isversionof10.1016/j.measurement.2024.116287en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCapsule dosage formen_US
dc.subjectContinuous wavelet transformen_US
dc.subjectDomperidoneen_US
dc.subjectLansoprazoleen_US
dc.subjectUV–Visible spectroscopyen_US
dc.titleApplication of continuous wavelet transforms for simultaneous estimation of domperidone and lansoprazole in capsule formulationsen_US
dc.titleApplication of continuous wavelet transforms for simultaneous estimation of domperidone and lansoprazole in capsule formulations
dc.typeArticleen_US

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