The effects of valproic acid on renal corpuscle of pregnant rats and protective role of folic acid and vitamin E

Basit Öğe Kaydı
dc.contributor.authorAktas, Ayfer
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorAkkus, Murat
dc.contributor.authorNasir, Yasemin
dc.date.accessioned2024-04-24T17:39:56Z
dc.date.available2024-04-24T17:39:56Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe aimed to investigate the potential harmful effects of valproic acid (VPA), a widely used anticonvulsant in child delivery, and the protective effects of vitamin E (Vit E) and folic acid (FA) on kidney. Sodium valproate (400 mg/kg), folic acid (400 mg/kg) and vitamin E (250 mg/kg) were administered to rats on each of gestation days, 8 (th), 9 (th), and 10 (th). The rats were sacrificed on the 20 th day of pregnancy. With thin sections of kidney biopsies, they were stained with uranyl acetate-lead citrate and examined under transmission electron microscope. The animals were divided into four groups randomly: control, VPA, VPA+FA and VPA+Vit E groups. In each group, drug procedure, surgical procedure and histological methods were performed. The histopathological findings of control group was normal. In VPA group, it showed degenerative changes especially in renal glomerular basal membrane and foot process. Both VPA+FA and VPA+Vit E groups exhibited similar ultrastructural changes and had almost the normal structure. Administration of single doses of SV (400 mg/kg) resulted in degenerative changes on kidney at ultrastructural level. Administration of FA and Vit E had a protective effect by preventing the degenerative changes to a certain degree. The aim of the present study is to examine histopathologic changes which may occur in a high risk experimental model after the administration of valproic acid. In addition, protective roles of the administration of folic acid and vitamin E are assessed.en_US
dc.identifier.endpage5610en_US
dc.identifier.issn1684-5315
dc.identifier.issue34en_US
dc.identifier.scopus2-s2.0-80052388950
dc.identifier.scopusqualityN/A
dc.identifier.startpage5605en_US
dc.identifier.urihttps://hdl.handle.net/11468/21440
dc.identifier.volume9en_US
dc.identifier.wosWOS:000281512100019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFolic Aciden_US
dc.subjectKidneyen_US
dc.subjectRaten_US
dc.subjectValproic Aciden_US
dc.subjectVitamin Een_US
dc.titleThe effects of valproic acid on renal corpuscle of pregnant rats and protective role of folic acid and vitamin Een_US
dc.titleThe effects of valproic acid on renal corpuscle of pregnant rats and protective role of folic acid and vitamin E
dc.typeArticleen_US

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