Effect of vitamin C at different doses on the oxidant/antioxidant system of ewes during late pregnancy, early and late lactation and their lambs

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dc.authorid0000-0003-1231-1431en_US
dc.authorid0000-0002-5140-2873en_US
dc.authorid0000-0003-0702-6660en_US
dc.contributor.authorGürgöze, Sema
dc.contributor.authorAlak, İlyas
dc.contributor.authorDurak, Mehmet Hanifi
dc.date.accessioned2024-04-15T12:05:21Z
dc.date.available2024-04-15T12:05:21Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractBackground: The development of connective tissue in the fetus during the ruminant gestation period increases the need for vitamin C, which is then further increased by the course of pregnancy and lactation. As pregnancy and lactation develop, free radicals and MDA produced as a result of oxidative stress interact with functional groups in the cell, resulting in cell damage. The oxidant/antioxidant balance at this time can be calculated using the total antioxidant status, total oxidant status and oxidative status index values. This study aimed to investigate the effect of two different doses of vitamin C on oxidative stress indicators in late gestation, early and late lactation ewes and their offspring. Methods: In the study, 48 ewes of the German Meat Merino and Akkaraman breeds that were developed by crossbreeding were employed. After breeding, four groups were formed from pregnant and non-pregnant ewes. Negative Pregnancy Control group was formed from non-pregnant ewes. Positive Pregnancy Control, Positive Pregnancy Practice 1 and Positive Pregnancy Practice 2 groups were formed from pregnant ewes. After the 90th day of pregnancy, ewes in the Negative Pregnancy Control and Positive Pregnancy Control groups received saline (0.9% NaCl, 2.5 ml) injections every week concurrently with the other pregnant groups until delivery. From the 90th day of pregnancy until birth, sheep participating in Positive Pregnancy Practices 1 and 2 received weekly injections of vitamin C (625 mg/CA, 2.5 ml and 1250 mg/CA, 5 ml, respectively). Result: In the study, no statistically significant difference was found in serum MDA, TAS, TOS and OSI levels between late pregnancy, lactation and born lambs. While none of the pregnant ewes in this study aborted, vitamin C injection significantly decreased postnatal lamb mortality. This showed that vitamin C helped pregnant ewes feel less stressed throughout pregnancy and helped lower postnatal lamb mortality. In pregnant ewes, AO-effective vitamin C supplementation has been shown to have possible beneficial effects on both maternal and offspring health, whereby the number of stillbirths was reduced by vitamin C supplementation, especially in Positive Pregnancy Practice 2 lambs.en_US
dc.identifier.citationGürgöze, S., Alak, İ. ve Durak, M. H. (2024). Effect of vitamin C at different doses on the oxidant/antioxidant system of ewes during late pregnancy, early and late lactation and their lambs. Indian Journal of Animal Research, 58(1), 56-60.en_US
dc.identifier.doi10.18805/IJAR.BF-1637
dc.identifier.endpage60en_US
dc.identifier.issn0367-6722
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85184879630
dc.identifier.scopusqualityQ3
dc.identifier.startpage56en_US
dc.identifier.urihttps://arccjournals.com/journal/indian-journal-of-animal-research/BF-1637
dc.identifier.urihttps://hdl.handle.net/11468/13870
dc.identifier.volume58en_US
dc.indekslendigikaynakScopus
dc.institutionauthorGürgöze, Sema
dc.institutionauthorDurak, Mehmet Hanifi
dc.language.isoenen_US
dc.publisherAgricultural Research Communication Centreen_US
dc.relation.ispartofIndian Journal of Animal Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectEween_US
dc.subjectLactationen_US
dc.subjectOxidanten_US
dc.subjectPregnanten_US
dc.subjectVitamin Cen_US
dc.titleEffect of vitamin C at different doses on the oxidant/antioxidant system of ewes during late pregnancy, early and late lactation and their lambsen_US
dc.titleEffect of vitamin C at different doses on the oxidant/antioxidant system of ewes during late pregnancy, early and late lactation and their lambs
dc.typeArticleen_US

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