Synthesis of novel oxime and benzofuran chemical frameworks possessing potent anticholinesterase activity: A SAR study related to alzheimer disease

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dc.authorid0000-0002-0704-6306en_US
dc.authorid0000-0002-9250-0293en_US
dc.authorid0000-0003-4163-9962en_US
dc.authorid0000-0001-8516-6525en_US
dc.authorid0000-0003-3777-5320en_US
dc.contributor.authorYılmaz, Anıl
dc.contributor.authorKoca, Murat
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorKurt, Adnan
dc.contributor.authorÖztürk, Turan
dc.date.accessioned2023-10-30T08:26:33Z
dc.date.available2023-10-30T08:26:33Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractAlzheimer Disease (AD) is a neurological disorder that causes the brain to shrink and brain cells to eventually die. Main symptom of AD is dementia. Today, approximately 50 million people worldwide are estimated to have AD. However, there is not a determined cure known against AD today. There are just four drugs against AD on the market. Unfortunately, none of them can totally destroy AD. Thus, discovering new molecules having capability to treat AD is required and significant. Benzofurans and oximes demonstrate a number of biological effects including anti-inflammatory and brain-barrier penetrating. For this reason, a number of novel compounds bearing oxime and benzofuran skeletons were designed and synthesized, and their anticholinesterase activities were investigated. Based on the results, several molecules demonstrated very strong anticholinesterase activities against both AChE and BChE enzymes, even much better than the reference drug molecule, Galantamine. Besides, structure-activity relationship (SAR) studies belonging to these chemical cores were revealed through this study for the first time. Various derivatives with different types of selective activities were obtained, which brightens the detailed SAR tendency of these molecules. This study can contribute to discover a novel lead drug molecule against AD, which is an urgent need.en_US
dc.identifier.citationYılmaz, A., Koca, M., Boğa, M., Kurt, A. ve Turan, Ö. (2023). Synthesis of novel oxime and benzofuran chemical frameworks possessing potent anticholinesterase activity: A SAR study related to alzheimer disease. ChemistrySelect, 8(30), 1-9.en_US
dc.identifier.doi10.1002/slct.202302058
dc.identifier.endpage9en_US
dc.identifier.issn2365-6549
dc.identifier.issue30en_US
dc.identifier.scopus2-s2.0-85167342263
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202302058
dc.identifier.urihttps://hdl.handle.net/11468/12996
dc.identifier.volume8en_US
dc.identifier.wosWOS:001045166200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofChemistrySelect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimeren_US
dc.subjectAnticholinesteraseen_US
dc.subjectBenzofuranen_US
dc.subjectOximeen_US
dc.subjectStructure-activity relationshipen_US
dc.titleSynthesis of novel oxime and benzofuran chemical frameworks possessing potent anticholinesterase activity: A SAR study related to alzheimer diseaseen_US
dc.titleSynthesis of novel oxime and benzofuran chemical frameworks possessing potent anticholinesterase activity: A SAR study related to alzheimer disease
dc.typeArticleen_US

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