The role of inflammatory parameters in predicting disease recurrence in patients with stage IIA colon cancer with no high-risk features

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dc.contributor.authorErdur, Erkan
dc.contributor.authorYildirim, Ozgen Ahmet
dc.contributor.authorPoyraz, Kerem
dc.contributor.authorAslan, Ferit
dc.contributor.authorYildiz, Fatih
dc.contributor.authorKomek, Halil
dc.date.accessioned2024-04-24T16:24:20Z
dc.date.available2024-04-24T16:24:20Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: We aimed to investigate the roles of inflammatory parameters, including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), and C-reactive protein/albumin ratio (CAR), in predicting disease recurrence in patients with stage IIA (T3N0M0) high microsatellite instability and microsatellite-stable colon cancer who had no risk factors associated with relapse. Materials and methods: We evaluated 155 patients with colon cancer followed in 3 hospitals in Turkey between February 2009 and March 2020. These patients had stage IIA disease and had no risk factors associated with relapse. None of the patients received adjuvant chemotherapy. NLR, PLR, LMR, and CAR parameters were retrospectively obtained from laboratory results at the time of diagnosis, and their associations with disease recurrence were assessed. Results: Over a median follow-up period of 38 months (range: 4-98 months), 11 of the 155 patients experienced relapse or developed metastases. Multivariate Cox analyses revealed that NLRs of >= 3.12 (hazard ratio [HR]: 0.041, 95% confidence interval [CI]: 0.048-0.826, p = 0.006) and CARs of >= 0.027 (HR: 0.199, 95% CI: 0.004-0.404, p = 0.026) were independent prognostic markers predicting relapse. The median 5-year recurrence-free survival rate of patients with NLRs of >= 3.12 at the time of diagnosis was 88.0%; this rate was 100% in patients with NLRs of <3.12 (p < 0.001). Similarly, the median 5-year recurrence-free survival rate of patients with CARs of >= 0.027 at the time of diagnosis was 84.7%; this rate was 95.7% in patients with CARs of <0.027 (p = 0.016). Conclusion: In this study, NLR and CAR were found to be independent prognostic markers predicting disease recurrence in patients with stage IIA colon cancer who did not receive adjuvant chemotherapy due to low clinical risk.en_US
dc.identifier.doi10.1080/00325481.2021.1934493
dc.identifier.endpage700en_US
dc.identifier.issn0032-5481
dc.identifier.issn1941-9260
dc.identifier.issue6en_US
dc.identifier.pmid34030576
dc.identifier.startpage694en_US
dc.identifier.urihttps://doi.org/10.1080/00325481.2021.1934493
dc.identifier.urihttps://hdl.handle.net/11468/16655
dc.identifier.volume133en_US
dc.identifier.wosWOS:000657162000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPostgraduate Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColon Carcinomaen_US
dc.subjectNeutrophilen_US
dc.subjectLymphocyteen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectAlbuminen_US
dc.titleThe role of inflammatory parameters in predicting disease recurrence in patients with stage IIA colon cancer with no high-risk featuresen_US
dc.titleThe role of inflammatory parameters in predicting disease recurrence in patients with stage IIA colon cancer with no high-risk features
dc.typeArticleen_US

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