The Effects of Pomegranate and Carvacrol on Methotrexate-Induced Bone Marrow Toxicity in Rats

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dc.contributor.authorSen, Velat
dc.contributor.authorBozkuri, Mehtap
dc.contributor.authorSoker, Sevda
dc.contributor.authorEce, Aydin
dc.contributor.authorGunes, Ali
dc.contributor.authorUluca, Unal
dc.contributor.authorSoker, Murat
dc.date.accessioned2024-04-24T17:44:37Z
dc.date.available2024-04-24T17:44:37Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to evaluate the e ff ects of pomegranate (PMG) extract and carvacrol (CARV) on methotrexate (MTX)- induced oxidative stress and bone marrow toxicity. Methods: Wistar albino rats (32 rats) were divided into four groups (n=8): Group 1 was control; Group 2 was given a single intraperitoneal injection of methotrexate (20 mg/kg); Group 3 was treated with carvacrol (73 mg/kg i.p.) one day before MTX (20 mg/kg i.p.) injection; and, Group 4 received a single dose of MTX (20 mg/kg i.p) while PMG was administered orally for seven days at 225 mg/kg. After animals were euthanized, blood samples were taken to evaluate hematological parameters and oxidative stress. In addition, the femur was cropped and bone marrow was extracted for examination. Results: White blood cell count, hemoglobin, hematocrit and platelet count were found to be decreased in the MTX group, but these changes were prevented in the groups that received CARV and PMG. Furthermore, decreased bone marrow cellularity was found in the groups treated with MTX, whereas the PMG and CARV groups had cellularity similar to controls. Strikingly, oxidative stress increased in the MTX group, but was ultimately decreased in the rats that received the antioxidants PMG and CARV. Conclusion: Carvacrol and PMG were found to be protective against methotrexateinduced oxidative bone marrow damage. Use of these antioxidants, in combination with chemotherapeutics, may help to reduce some adverse effects of methotrexate.en_US
dc.description.sponsorshipDicle University coordination committee of scientific research projects (DUBAP)en_US
dc.description.sponsorshipFinancial support was provided by Dicle University coordination committee of scientific research projects (DUBAP).en_US
dc.identifier.endpageE101en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue2en_US
dc.identifier.pmid24690424
dc.identifier.startpageE93en_US
dc.identifier.urihttps://hdl.handle.net/11468/22193
dc.identifier.volume37en_US
dc.identifier.wosWOS:000334296500006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe Effects of Pomegranate and Carvacrol on Methotrexate-Induced Bone Marrow Toxicity in Ratsen_US
dc.titleThe Effects of Pomegranate and Carvacrol on Methotrexate-Induced Bone Marrow Toxicity in Rats
dc.typeArticleen_US

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