ADM and SFLT-1 Eexpression in placentas with gestational diabetes mellitus

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dc.authorid0000-0002-5703-9892en_US
dc.authorid0000-0001-6453-0033en_US
dc.authorid0000-0003-0734-2428en_US
dc.authorid0000-0001-5203-9650en_US
dc.authorid0000-0002-6384-9146en_US
dc.authorid0000-0002-2353-1184en_US
dc.authorid0000-0002-1693-6378en_US
dc.contributor.authorArslan, Necat
dc.contributor.authorSöker, Sevda İpek
dc.contributor.authorBaşaran, Süreyya Özdemir
dc.contributor.authorKaplan, Özge
dc.contributor.authorAşır, Fırat
dc.contributor.authorDeveci, Engin
dc.contributor.authorŞeker, Uğur
dc.date.accessioned2023-11-30T06:17:36Z
dc.date.available2023-11-30T06:17:36Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractAim: In this study, we aimed to examine the expression levels of Adrenomedullin (ADM) and soluble fms-like tyrosine kinase-1 (sFlt-1), two novel proteins found to be involved in vascular regulation in gestational diabetes mellitus (GDM), to compare the expression levels of these proteins in the histopathology of the disease and to observe the correlation of the expression intensity of these proteins with the disease. Methods: In our study, 20 healthy and 20 GDM placenta samples were obtained. Histologic followup was performed. 5µm thick sections were taken from these tissues and stained with HematoxylinEosin and Periodic Acid Schiff (PAS). Immunohistochemically, ADM and sFlt-1 antibodies were studied. Results: In the GDM group, vascular dilatation and congestion in stem villus, hyperplasic endothelial cells, and increased syncytial bridges in the external part of the villi, mononuclear cell infiltration, pyknotic nuclei and cytoplasm loss in some of the decidual cells in the maternal region were observed. In the immunohistochemical examination, cytotrophoblast and syncytiotrophoblast cells of villous and syncytial nodes showed negative ADM expression. ADM was positively expressed in some cytotrophoblast cells of small villi, vascular endothelial cells and decidual cells. In the GDM group, sFlt-1 expression was positive in endothelial cells, some Hofbauer cells of mesenchymal connective tissue, decidual cell nuclei and membranes. Conclusions: ADM may be an important receptor in insulin metabolism to determine the glucose level because we found positive ADM expression in cytotrophoblasts and membranes of decidual cells. In addition, changes in endothelial cells of maternal and fetal regions and sFlt-1 expression in Hofbauer cells suggest that this molecule possibly plays a key role in the angiogenic effect.en_US
dc.identifier.citationArslan, N., Söker, S. İ., Başaran, S. Ö., Kaplan, Ö., Aşır, F., Deveci, E. ve diğerleri. (2023). ADM and SFLT-1 Eexpression in placentas with gestational diabetes mellitus. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, 6(1), 161-168.en_US
dc.identifier.doi10.36516/jocass.1269105
dc.identifier.endpage168en_US
dc.identifier.issn2667-498X
dc.identifier.issue1en_US
dc.identifier.startpage161en_US
dc.identifier.trdizinid1174951
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1174951
dc.identifier.urihttps://hdl.handle.net/11468/13066
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1174951
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorArslan, Necat
dc.institutionauthorSöker, Sevda İpek
dc.institutionauthorBaşaran, Süreyya Özdemir
dc.institutionauthorKaplan, Özge
dc.institutionauthorAşır, Fırat
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherMerthan Tunayen_US
dc.relation.ispartofÇukurova Anestezi ve Cerrahi Bilimler Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPlacentaen_US
dc.subjectGDMen_US
dc.subjectPASen_US
dc.subjectHematoxylin-eosinen_US
dc.subjectSFlt-1en_US
dc.subjectAdrenomedullinen_US
dc.titleADM and SFLT-1 Eexpression in placentas with gestational diabetes mellitusen_US
dc.titleADM and SFLT-1 Eexpression in placentas with gestational diabetes mellitus
dc.typeArticleen_US

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