The effect of ofloxacin on pentobarbital-induced sleep in mice

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dc.contributor.authorEngdotnar, Nurhan
dc.contributor.authorEroǧlu, Lütfiye
dc.contributor.authorUlak, Güner
dc.date.accessioned2024-04-24T17:56:06Z
dc.date.available2024-04-24T17:56:06Z
dc.date.issued1991
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Famakoloji Ana Bilim Dalıen_US
dc.description.abstractThere have been several reports that insomnia occurs in some patients who receive ofloxacin. Since almost no experimental data on ofloxacin-induced insomnia were available, this study was conducted for the evaluation of ofloxacin effects on sleep parameters in mice. In Experiment 1, mice were pretreated with ofloxacin (20 or 40 mg/kg IP) or saline 15 minutes before sodium pentobarbital (35 mg/kg IP). Experiment 2 was carried out in two days. On the first day mice were treated twice, in the morning and in the evening, with ofloxacin (20 or 80 mg/kg IP) or saline. On the second morning, mice were pretreated with the same doses of ofloxacin or saline 15 minutes before sodium pentobarbital (35 mg/kg IP). Sleep latency and sleeping time were recorded in each experiment. Results showed that ofloxacin had no apparent effect on sleep latency, but caused a shortening in sleeping time. However, this effect was significant only in the 40 and 80 mg/kg ofloxacin-treated groups.en_US
dc.identifier.citationEngdotnar, N., Eroǧlu, L. ve Ulak, G. (1991). The effect of ofloxacin on pentobarbital-induced sleep in mice. Pharmacology, Biochemistry and Behavior, 40(1), 65-67.
dc.identifier.doi10.1016/0091-3057(91)90321-R
dc.identifier.endpage67en_US
dc.identifier.issn0091-3057
dc.identifier.issue1en_US
dc.identifier.pmid1780346
dc.identifier.scopus2-s2.0-0025994391
dc.identifier.scopusqualityQ1
dc.identifier.startpage65en_US
dc.identifier.urihttps://doi.org/10.1016/0091-3057(91)90321-R
dc.identifier.urihttps://hdl.handle.net/11468/23281
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/009130579190321R?via%3Dihub
dc.identifier.volume40en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUlak, Güner
dc.language.isoenen_US
dc.relation.ispartofPharmacology, Biochemistry and Behavior
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMiceen_US
dc.subjectOfloxacinen_US
dc.subjectSleep latencyen_US
dc.subjectSleeping timeen_US
dc.subjectSodium pentobarbitalen_US
dc.titleThe effect of ofloxacin on pentobarbital-induced sleep in miceen_US
dc.titleThe effect of ofloxacin on pentobarbital-induced sleep in mice
dc.typeArticleen_US

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