The effects of GnRH analogues and antiandrogenes in preventing the gonadotoxic effects of COPP chemotherapy

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dc.contributor.authorGöçmen, Mustafa
dc.contributor.authorAkay, Ali Ferruh
dc.contributor.authorŞahin, Hayrettin
dc.contributor.authorDeniz, Mustafa
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorBircan, Mehmet Kamuran
dc.contributor.orcid0000-0002-0854-0904
dc.date.accessioned2024-04-24T17:56:13Z
dc.date.available2024-04-24T17:56:13Z
dc.date.issued2001
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalıen_US
dc.description.abstractBackground: In this study we aimed to discuss whether the gonadal suppression is effective or not in preventing the gonadal toxic effects of some chemotherapeutics. Methods: Forty Sprague-Dawley adult male rats were randomised into 4 groups, each consisting of 10. No drugs were given to the first group. The second group received GnRH agonist and antiandrogen, the third group received COPP chemotherapy protocol and the last group received COPP together with GnRH agonist and antiandrogen. Ninety days after drug application we sacrificed all rats. Total body weight, testicular weight and testicular size measurements were all recorded. All testicular tissues were examined histologically for the ratio of active seminiferous tubules. Results: There was no difference in total body weight. The weight and measurements of testicular tissues were decreased in-group 3 and 4 when compared with 1 and 2. The amount of active seminiferous tubules was significantly less in the third group. Conclusions: As a conclusion we think that gonadal suppression applied during chemotherapy regimen could decrease the testicular toxic effects of chemotherapeutic but more clinical investigations needed for routine application.en_US
dc.identifier.citationGöçmen, M., Akay, A. F., Şahin, H., Deniz, M., Nergiz, Y. ve Bircan, M. K. (2001). The effects of GnRH analogues and antiandrogenes in preventing the gonadotoxic effects of COPP chemotherapy. International Urology and Nephrology, 33(4), 651-654.
dc.identifier.doi10.1023/A:1020518916072
dc.identifier.endpage654en_US
dc.identifier.issn0301-1623
dc.identifier.issue4en_US
dc.identifier.pmid12452621
dc.identifier.scopus2-s2.0-0035779812
dc.identifier.scopusqualityQ2
dc.identifier.startpage651en_US
dc.identifier.urihttps://doi.org/10.1023/A:1020518916072
dc.identifier.urihttps://hdl.handle.net/11468/23375
dc.identifier.urihttps://link.springer.com/article/10.1023/A:1020518916072
dc.identifier.volume33en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiandrogenen_US
dc.subjectCoppen_US
dc.subjectGnrh Analoguesen_US
dc.subjectGonadotoxicen_US
dc.subjectRaten_US
dc.titleThe effects of GnRH analogues and antiandrogenes in preventing the gonadotoxic effects of COPP chemotherapyen_US
dc.titleThe effects of GnRH analogues and antiandrogenes in preventing the gonadotoxic effects of COPP chemotherapy
dc.typeArticleen_US

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