Tulathromycin disturbs blood oxidative and coagulation status

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dc.contributor.authorEr, Ayse
dc.contributor.authorUlutas, Elmas
dc.contributor.authorAltan, Feray
dc.contributor.authorCetin, Gul
dc.contributor.authorBulbul, Aziz
dc.contributor.authorElmas, Muammer
dc.contributor.authorYazar, Enver
dc.date.accessioned2024-04-24T17:40:00Z
dc.date.available2024-04-24T17:40:00Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effect of tulathromycin on serum oxidative status and coagulation factors in rabbits. Tulathromycin was administered to eight rabbits, and blood samples were obtained 0, 1, 5, 10 and 15 days after treatment. Indicators of serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol and beta-carotene) and coagulation values (antithrombin III, fibrinogen) were measured after tulathromycin treatment. In addition, routine serum biochemical values (creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high density lipoprotein, amylase, total protein, albumin, glucose and calcium), haemacell counts (white and red blood cells) and arterial blood gas parameters (packed cell volume, hemoglobin, pH, partial pressure of carbon dioxide, partial pressure of oxygen, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, sodium and potassium) were also determined. Tulathromycin increased (P < 0.05) the levels of malondialdehyde, nitric oxide and superoxide dismutase activity, and decreased (P < 0.05) the level of antithrombin III. In conclusion, tulathromycin may cause oxidative damage and coagulation disorders during the treatment period.en_US
dc.identifier.endpage3247en_US
dc.identifier.issn1684-5315
dc.identifier.issue16en_US
dc.identifier.scopus2-s2.0-79955551701
dc.identifier.scopusqualityN/A
dc.identifier.startpage3243en_US
dc.identifier.urihttps://hdl.handle.net/11468/21508
dc.identifier.volume10en_US
dc.identifier.wosWOS:000290666800033
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTulathromycinen_US
dc.subjectOxidative Damageen_US
dc.subjectCoagulation Disorderen_US
dc.titleTulathromycin disturbs blood oxidative and coagulation statusen_US
dc.titleTulathromycin disturbs blood oxidative and coagulation status
dc.typeArticleen_US

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