Metal chelate based site recognition of ceruloplasmin using molecularly imprinted polymer/cryogel system

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dc.contributor.authorDolak, Ibrahim
dc.contributor.authorCanpolat, Gurbet
dc.contributor.authorErsoz, Arzu
dc.contributor.authorSay, Ridvan
dc.date.accessioned2024-04-24T16:24:28Z
dc.date.available2024-04-24T16:24:28Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn the present study, N-Acetylneuraminic acid (NANA)-imprinted poly(2-hydroxyethyl methacrylate-N-methacryloyl-(L)-histidin-Cu(II)) p(HEMA-(MAH)(2)-Cu(II)) has been synthesized by radical polymerization for site recognition of ceruloplasmin. Prepared imprinted cryogel has been characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). When the binding capacity of NANA-imprinted cryogel (MIP) was compared with non-imprinted cryogel (NIP), it was found that MIP has higher adsorption capacity. The maximum amount of binding NANA has found as 83.20 mgg(-1) at pH 7.0 with flow rate of 1 mLmin(-1) at 25 degrees C. Selectivity experiments for MIP and NIP cryogel have been carried out via the NANA/D-mannose and ceruloplasmin/immunoglobulin G (IgG) pair separately and the relative selectivity coefficient (k') has found as 77.46 and 17.97, respectively. Applicable of the MIP in human serum has been studied and resulted successfully.en_US
dc.identifier.doi10.1080/01496395.2019.1577446
dc.identifier.endpage208en_US
dc.identifier.issn0149-6395
dc.identifier.issn1520-5754
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85062329061en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage199en_US
dc.identifier.urihttps://doi.org/10.1080/01496395.2019.1577446
dc.identifier.urihttps://hdl.handle.net/11468/16727
dc.identifier.volume55en_US
dc.identifier.wosWOS:000501379700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofSeparation Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCeruloplasminen_US
dc.subjectNana-Imprinted Cryogelen_US
dc.subjectMetal-Chelate Complexen_US
dc.subjectP-Hema-Mahen_US
dc.subjectSelective Separationen_US
dc.titleMetal chelate based site recognition of ceruloplasmin using molecularly imprinted polymer/cryogel systemen_US
dc.typeArticleen_US

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