No evidence of androgenic neurosteroid involvement in pediatric OCD

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dc.contributor.authorErbay, Lale Gonenir
dc.contributor.authorOzcan, Ozlem Ozel
dc.contributor.authorKartalci, Sukru
dc.contributor.authorYuksel, Tugba
dc.contributor.authorKutuk, Meryem Ozlem
dc.date.accessioned2024-04-24T16:15:12Z
dc.date.available2024-04-24T16:15:12Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractCertain androgenic neurosteroids have been shown to have a relationship with anxiety disorders in adults. Demonstrating these changes in pediatric patients as well is important in terms of elucidating the etiology of these disorders. The aim of this study was to investigate the testosterone, DHEA-S and cortisol levels in pediatric obsessive-compulsive disorder (OCD) patients. A total of 39 pediatric OCD patients aged 7-16 years and 34 healthy children of similar age and gender were included in this study. Serum total testosterone, DHEA-S and cortisol levels were measured by using the ELISA method and their relationship with clinical data was investigated. No statistically significant difference was found between the patient and control groups in terms of testosterone, DHEA-A and cortisol levels in the analyses performed (p=0.175, p=0.642. p=0.842. respectively). The results of this first study have revealed that testosterone, DHEA-S and cortisol levels in pediatric OCD patients are not different than in the controls. However, the fact that these neurosteroid levels have been found to differ between adult patients and controls previously indicates that neurosteroid changes may be a finding that appears during the course of anxiety disorders. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocrd.2015.06.002
dc.identifier.endpage100en_US
dc.identifier.issn2211-3649
dc.identifier.scopus2-s2.0-84934277666en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage97en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocrd.2015.06.002
dc.identifier.urihttps://hdl.handle.net/11468/15699
dc.identifier.volume6en_US
dc.identifier.wosWOS:000359612400012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Obsessive-Compulsive and Related Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOcden_US
dc.subjectAndrogenic Neurosteroiden_US
dc.subjectChildhooden_US
dc.titleNo evidence of androgenic neurosteroid involvement in pediatric OCDen_US
dc.typeArticleen_US

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