Advanced-designed Ru(II) complexes containing phosphinite ligands derived from chiral amino alcohols: Electrochemical behavior, DFT calculations, and biological activity

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dc.authoridISIK, UGUR/0000-0003-1010-9563
dc.contributor.authorMeric, Nermin
dc.contributor.authorIsik, Ugur
dc.contributor.authorDauletbakov, Anuar
dc.contributor.authorZolotareva, Darya
dc.contributor.authorZazybin, Alexey
dc.contributor.authorSever, Mehmet Serif
dc.contributor.authorOkumus, Veysi
dc.date.accessioned2025-02-22T14:09:00Z
dc.date.available2025-02-22T14:09:00Z
dc.date.issued2025
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe report two phosphinite ligands derived from chiral amino alcohols, and their complexes with ruthenium(II). These compounds were characterized by spectroscopic methods. Then, antimicrobial, antioxidant, and DNA binding activities of the chiral Ru(II)-phosphinite complexes were tested. Complex (1R)-2-{benzyl[(1S)-1(naphthalen-1-yl)ethyl]amino}-1-phenylethyl diphenylphos- phinito[dichloro(eta 6-p-cymene)ruthenium(II)], 7 showed both the highest radical scavenging activity (90.93 +/- 0.98 %) and the highest metal chelating activity (65.45 +/- 1.46 %) at 200.0 mg l-1 concentration. In addition, all of complexes had different rates of binding activity to calf thymus DNA (CT-DNA). Moreover, extensive theoretical and experimental investigations were conducted to gain a more profound understanding of the chemical descriptors and the diverse electronic transitions taking place within the ruthenium complexes, as well as their electrochemical characteristics.en_US
dc.description.sponsorshipMinister of Science and Higher Educa-tion of the Republic of Kazakhstan [AP19578051]; Dicle University [FEN.24.020]en_US
dc.description.sponsorshipThe research was funded by Minister of Science and Higher Educa-tion of the Republic of Kazakhstan (Grant No: AP19578051) . Partial supports of this work by Dicle University (Project number: FEN.24.020) is gratefully acknowledged.en_US
dc.identifier.doi10.1016/j.jorganchem.2024.123410
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85207257912en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2024.123410
dc.identifier.urihttps://hdl.handle.net/11468/29753
dc.identifier.volume1023en_US
dc.identifier.wosWOS:001345791700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectChiral amino alcoholsen_US
dc.subjectRuthenium complexesen_US
dc.subjectBiological propertiesen_US
dc.subjectDFT calculationsen_US
dc.subjectElectrochemical behavioren_US
dc.titleAdvanced-designed Ru(II) complexes containing phosphinite ligands derived from chiral amino alcohols: Electrochemical behavior, DFT calculations, and biological activityen_US
dc.typeArticleen_US

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