Hyaluronic Acid as a New Biomarker to Differentiate Acute Kidney Injury From Chronic Kidney Disease

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dc.contributor.authorAkin, Davut
dc.contributor.authorOzmen, Sehmus
dc.contributor.authorYilmaz, Mehmet Emin
dc.date.accessioned2024-04-24T17:48:02Z
dc.date.available2024-04-24T17:48:02Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction. It may be difficult to differentiate acute kidney injury from chronic kidney disease in patients with no past medical reports of kidney function. This study aimed to investigate the role of serum hyaluronic acid (HA), which is known as a marker of fibrosis, in differential diagnosis of kidney failure. Materials and Methods. A total of 90 patients (52 women and 38 mne) admitted to our renal unit with uremia for the first time were included. Serum HA level was measured. The diagnostic role of the test was investigated using the receiver operator curve curves. Results. The mean age of the patients was 54.6 +/- 17.9 years. The diagnosis was chronic kidney disease (CKD) in 41.1%, acute kidney injury (AKI) in 48.9%, AKI on CKD in 6.7% (3 died without a diagnosis). The mean serum HA was significantly higher in the CKD group (146.1 +/- 119.3 ng/mL) than the AKI group (68.9 +/- 69.1 ng/mL; P < .001). Serum HA significantly correlated with proteinuria (r = 0.717, P < .001) and serum albumin level (r = -0.599, P < .001) in the CKD group only. Serum HA cutoff level of 61 ng/dL had a sensitivity of 82% and specificity of 67% for differential diagnosis of AKI and CKD. Conclusions. Serum HA level may be used as tool to differentiate AKI from CKD. Further larger studies are warranted to clarify the definite the role of this marker.en_US
dc.identifier.endpage413en_US
dc.identifier.issn1735-8582
dc.identifier.issn1735-8604
dc.identifier.issue6en_US
dc.identifier.pmid29190600
dc.identifier.startpage409en_US
dc.identifier.urihttps://hdl.handle.net/11468/22857
dc.identifier.volume11en_US
dc.identifier.wosWOS:000417093300003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherIranian Soc Nephrolgyen_US
dc.relation.ispartofIranian Journal of Kidney Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyaluronic Aciden_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectAcute Kidney Injuryen_US
dc.titleHyaluronic Acid as a New Biomarker to Differentiate Acute Kidney Injury From Chronic Kidney Diseaseen_US
dc.titleHyaluronic Acid as a New Biomarker to Differentiate Acute Kidney Injury From Chronic Kidney Disease
dc.typeArticleen_US

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