Relationship between clinical and histopathological features of patients undergoing cholecystectomy

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dc.contributor.authorAkbulut, Sami
dc.contributor.authorYagmur, Yusuf
dc.contributor.authorSakarya, Hamdi
dc.contributor.authorBahce, Zeynep Sener
dc.contributor.authorGumus, Serdar
dc.contributor.authorSogutcu, Nilgun
dc.date.accessioned2024-04-24T17:24:53Z
dc.date.available2024-04-24T17:24:53Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: Cholelithiasis is most common disease of the gallbladder and cholecystectomy is the one of the most performed surgical procedure worldwide. Aim: To assess the relationship between the demographic, biochemical, and histopathological variables of patients who underwent cholecystectomy. Material and methods: Demographic, biochemical, and histopathological data of 5077 patients undergoing cholecystectomy were compared in terms of two different aspects: open cholecystectomy (OC group; n = 2090) versus laparoscopic cholecystectomy (LC group; n = 2987), and an elective group (n = 4814) versus an emergency group (n = 263). Results: A total of 5077 patients aged between 13 and 97 years were included in the study. Aspartate aminotransferase (AST) levels, alanine aminotransferase (ALT) levels, mean platelet volume, and prevalence of acute/chronic cholecystitis were significantly higher in the LC group than in the OC group. On the other hand, age, direct bilirubin level, thrombocyte count, and prevalence of gallbladder cancer/gangrenous cholecystitis were significantly higher in the OC group than in the LC group. Levels of AST, ALT, white blood cells, neutrophils, and some prevalence of acute/chronic active cholecystitis were higher in the emergency group than in the elective group. On the other hand, the lymphocyte count and prevalence of chronic cholecystitis/hyperplastic polyps were higher in the elective group than in the emergency group. Histopathological analysis identified 32 patients with malignant gallbladder cancer as follows: adenocarcinoma (n = 21), mucinous adenocarcinoma (n = 3), papillary adenocarcinoma (n = 3), adenosquamous carcinoma (n = 1), clear cell adenocarcinoma (n = 2), squamous carcinoma (n = 1), and hepatocellular carcinoma metastasis (n = 1). Conclusions: Even when the appearance of gallbladder specimens is normal, histopathological assessment allows for early diagnosis of many unusual findings such as gallbladder cancer.en_US
dc.identifier.doi10.5114/pg.2019.86772
dc.identifier.endpage137en_US
dc.identifier.issn1895-5770
dc.identifier.issn1897-4317
dc.identifier.issue2en_US
dc.identifier.pmid32550945
dc.identifier.startpage131en_US
dc.identifier.urihttps://doi.org/10.5114/pg.2019.86772
dc.identifier.urihttps://hdl.handle.net/11468/19867
dc.identifier.volume15en_US
dc.identifier.wosWOS:000540337000008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofGastroenterology Review-Przeglad Gastroenterologiczny
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCholelithiasisen_US
dc.subjectCholecystitisen_US
dc.subjectUnusual Findingsen_US
dc.subjectGallbladder Canceren_US
dc.titleRelationship between clinical and histopathological features of patients undergoing cholecystectomyen_US
dc.titleRelationship between clinical and histopathological features of patients undergoing cholecystectomy
dc.typeArticleen_US

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