P53, c-erbB-2 expression and steroid hormone receptors in breast carcinoma

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dc.contributor.authorKilinç, N
dc.contributor.authorYaldiz, M
dc.date.accessioned2024-04-24T17:40:45Z
dc.date.available2024-04-24T17:40:45Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of the study was to evaluate the p53 tumor suppressor gene, c-erbB-2 and steroid hormone receptor expression in breast carcinoma by immunohistochemistry and to correlate them with different histopathologic parameters. Materials and Methods: p53, c-erbB-2, steroid hormone receptors and their correlation with age, tumor size, histological grade, axillary lymph-node status, and menopausal status were investigated in 65 breast carcinoma cases. All markers were measured immunohistochemically on paraffin sections. Association between estrogen receptor (ER), progesterone receptor (PgR), p53 and c-erbB-2 expression and clinicopathologic variables were assessed by the chi-square test for qualitative parameters. Results: c-erbB-2 staining was found in 35.3% of breast carcinomas and was associated with ductal subtype and age under 35 (p 0.022, p = 0.003, respectively); p53 staining was seen in 27.6% of cases and was associated with high histological grade and post-menapausal status (p = 0.038, p = 0.002, respectively). Progesterone receptor expression was associated with positive axillary status (p = 0.003). Conclusion: We concluded that expressions of c-erbB-2, p53, ER, and PgR may be used in the evaluation of breast carcinoma. Therefore the present study suggests that p53 expression is a marker of high histological grade in postmenopausal status, and that c-erbB-2 expression is associated with histologically ductal subtype.en_US
dc.identifier.endpage610en_US
dc.identifier.issn0392-2936
dc.identifier.issn2709-0086
dc.identifier.issue5en_US
dc.identifier.pmid15493177
dc.identifier.startpage606en_US
dc.identifier.urihttps://hdl.handle.net/11468/21936
dc.identifier.volume25en_US
dc.identifier.wosWOS:000224169800016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherImr Pressen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Carcinomaen_US
dc.subjectP53en_US
dc.subjectC-Erbb-2en_US
dc.subjectEstrogen Receptoren_US
dc.subjectProgesterone Receptoren_US
dc.titleP53, c-erbB-2 expression and steroid hormone receptors in breast carcinomaen_US
dc.titleP53, c-erbB-2 expression and steroid hormone receptors in breast carcinoma
dc.typeArticleen_US

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