Characterization, antibacterial, anticarbonic anhydrase II isoenzyme, anticancer, electrochemical and computational studies of sulfonic acid hydrazide derivative and its Cu(II) complex

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dc.contributor.authorOzdemir, Ummuhan O.
dc.contributor.authorAktan, Ebru
dc.contributor.authorIlbiz, Firdevs
dc.contributor.authorGunduzalp, Ayla B.
dc.contributor.authorOzbek, Neslihan
dc.contributor.authorSari, Musa
dc.contributor.authorCelik, Omer
dc.date.accessioned2024-04-24T16:14:52Z
dc.date.available2024-04-24T16:14:52Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractA new N'-acetyl butane sulfonic acid hydrazide, C4H9-SO2-NH-NH-COCH3 (Absh, an sulfonamide compound), and its Cu(II) complex [Cu(Absh)(2)(CH3COO)(2)], have been synthesized and characterized by elemental analysis, spectrometric methods (H-1-C-13 NMR, FT-IR, LC-MS), thermal analysis, magnetic susceptibility and conductivity measurements. In addition, molecular structure of the ligand, Absh was determined by single crystal X-ray diffraction technique and found that the compound crystallizes in monoclinic, space group P2(1)/c. To gain information about the structure of the ligand and its complex, we have performed computational studies using density functional theory (DFT) for optimized geometries of the compounds. Electrochemical studies showed that, the complex is electrochemically active and has one irreversible reduction and one irreversible oxidation potentials, and the half wave reduction potentials are -1.15 and 0.45 volt respectively, versus ferrocene/ferrocenium internal reference electrode. The antibacterial activities of synthesized compounds were studied against Gram positive bacteria; Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633, Bacillus cereus NRRL-B-3711, Enterococcus faecalis ATCC 29212 and Gram negative bacteria; Escherichia coli ATCC 11230, Pseudomonas aeruginosa ATCC 15442, Klebsiella pneumonia ATCC 70063 by using the disc diffusion and micro dilution methods. The inhibition activities of these compounds on carbonic anhydrase II enzyme (hCA II) have been investigated by comparing IC50 and K-i values. The anticancer activities of these compounds on MCF-7 cell line investigated by comparing IC50 values. The biological activity screening showed that Cu(II) complex has more activity than ligand against the tested bacteria, hCA II enzyme and breast cancer cell lines MCF-7. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipGazi University Research Found [05/2010-92]; TUBITAK [105T240]en_US
dc.description.sponsorshipThis research was supported by Gazi University Research Found under Project No. 05/2010-92 and TUBITAK Project No. 105T240. We thank Ankara University, Faculty of Pharmacy. Central Labs for allocation of time at the Mass Spectra and Elemental Analyses.en_US
dc.identifier.doi10.1016/j.ica.2014.09.033
dc.identifier.endpage203en_US
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-84910135887
dc.identifier.scopusqualityQ2
dc.identifier.startpage194en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2014.09.033
dc.identifier.urihttps://hdl.handle.net/11468/15461
dc.identifier.volume423en_US
dc.identifier.wosWOS:000345116000022
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectButane Sulfonic Acid Hydrazideen_US
dc.subjectCu(Ii) Complexen_US
dc.subjectBiological Activitiesen_US
dc.subjectElectrochemical Studiesen_US
dc.subjectCrystal Structureen_US
dc.subjectDften_US
dc.titleCharacterization, antibacterial, anticarbonic anhydrase II isoenzyme, anticancer, electrochemical and computational studies of sulfonic acid hydrazide derivative and its Cu(II) complexen_US
dc.titleCharacterization, antibacterial, anticarbonic anhydrase II isoenzyme, anticancer, electrochemical and computational studies of sulfonic acid hydrazide derivative and its Cu(II) complex
dc.typeArticleen_US

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