The Role of CD56, HBME-1, and p63 in Follicular Neoplasms of the Thyroid

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dc.contributor.authorEtem, Hulya
dc.contributor.authorOzekinci, Selver
dc.contributor.authorMizrak, Bulent
dc.contributor.authorSenturk, Senem
dc.date.accessioned2024-04-24T17:25:00Z
dc.date.available2024-04-24T17:25:00Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Carcinomas originating from thyroid follicular cells are the commonest of all endocrine system malignancies. In this study we evaluated the importance of the expressions of CD 56, HBME-1 and p63 in the differential diagnosis of the follicular variant of papillary carcinoma from other follicular neoplasms. Material and Method: We re-evaluated 80 cases of thyroid neoplasms, comprising 40 cases of follicular variant of papillary thyroid carcinoma and 40 cases of follicular neoplasm, diagnosed at Dicle University Medical School, Department of Pathology between 2005 and 2008. All neoplasms were stained with CD 56, HBME-1 and p 63 compared to each other. Statistical analysis was with Student's t test and the Yates corrected chi-square test. Result: There was no statistically significant difference in the expression of CD 56 between follicular neoplasms and papillary carcinomas, but HBME-1 and p63 expressions were statistically significantly different between these neoplasms (p=0.005, p=0.0001). Conclusion: The use of HBME-1 and p63 may be helpful in differentiating papillary carcinoma, particularly follicular variant, from follicular neoplasms.en_US
dc.description.sponsorshipDicle University Research Commissionen_US
dc.description.sponsorshipThis study has been supported by the Dicle University Research Commission.en_US
dc.identifier.doi10.5146/tjpath.2010.01030
dc.identifier.endpage242en_US
dc.identifier.issn1018-5615
dc.identifier.issn1309-5730
dc.identifier.issue3en_US
dc.identifier.startpage238en_US
dc.identifier.trdizinid105428
dc.identifier.urihttps://doi.org/10.5146/tjpath.2010.01030
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/105428
dc.identifier.urihttps://hdl.handle.net/11468/19903
dc.identifier.volume26en_US
dc.identifier.wosWOS:000217434700010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherFederation Turkish Pathology Socen_US
dc.relation.ispartofTurkish Journal of Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThyroid Canceren_US
dc.subjectPapillary Thyroid Carcinomaen_US
dc.subjectFollicular Neoplasmsen_US
dc.titleThe Role of CD56, HBME-1, and p63 in Follicular Neoplasms of the Thyroiden_US
dc.titleThe Role of CD56, HBME-1, and p63 in Follicular Neoplasms of the Thyroid
dc.typeArticleen_US

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