The Comparison of FLOT and DCF Regimens as Perioperative Treatment for Gastric Cancer

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dc.authoridUCAR, GOKHAN/0000-0002-7649-1075
dc.contributor.authorUcar, Gokhan
dc.contributor.authorSekmek, Serhat
dc.contributor.authorKarahan, Irfan
dc.contributor.authorErgun, Yakup
dc.contributor.authorIsak, ozlem Aydin
dc.contributor.authorTunc, Sezai
dc.contributor.authorDogan, Mutlu
dc.date.accessioned2025-02-22T14:08:50Z
dc.date.available2025-02-22T14:08:50Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: Locoregional gastric cancer is a still serious problem and perioperative treatments may improve the success of management. Different regimens were examined. The present study purposed to compare the efficacy of fl uorouracil-leucovorin-oxaliplatin-docetaxel (FLOT) and docetaxel-cisplatin-fluorouracil (DCF) regimens. Methods: A retrospective multicenter study assessed the patients with loco regional gastric cancer. There are 240 patients (137 DCF, 103 FLOT). Survival rates were compared. Results: Demographic features were similar between the two groups, but the time period was different. The FLOT group had 7.8% pathological complete response, while the DCF group did not. Disease-free survival was longer in the FLOT than in the DCF group (median not reached - 13.94 months, respectively). Median overall survival was similar (30.9 vs. 37.8 months), but median follow-up affected the analysis. Survival for 36 months was 63% for the FLOT group and 40% for the DCF group (log-rank; p = 0.015). Conclusion: FLOT regimen was superior to DCF regimen for response and survival rates. DCF is a historical approach. Long-term follow-up period is needed for FLOT treatment. (c) 2024 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000540517
dc.identifier.issn0030-2414
dc.identifier.issn1423-0232
dc.identifier.pmid39079501en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1159/000540517
dc.identifier.urihttps://hdl.handle.net/11468/29672
dc.identifier.wosWOS:001356204700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectGastric canceren_US
dc.subjectPerioperative treatmenten_US
dc.subjectFLOTen_US
dc.subjectDCFen_US
dc.titleThe Comparison of FLOT and DCF Regimens as Perioperative Treatment for Gastric Canceren_US
dc.typeArticleen_US

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