Bis(phosphinite) with C2-Symmetric Axis; Effects on the Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation of Acetophenone Derivatives

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dc.contributor.authorAydemir, Murat
dc.contributor.authorDurap, Feyyaz
dc.contributor.authorKayan, Cezmi
dc.contributor.authorBaysal, Akin
dc.contributor.authorTurgut, Yilmaz
dc.date.accessioned2024-04-24T16:24:09Z
dc.date.available2024-04-24T16:24:09Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractChiral ruthenium catalyst systems generated in situ from [Ru(eta(6)-p-cymene)(mu-Cl)Cl](2) complex and chiral C-2-symmetric bis(phosphinite) ligands based on amino alcohol derivatives were employed in the asymmetric transfer hydrogenation of aromatic ketones to give the corresponding optically active alcohols in high yield. The best results were obtained in the [Ru(eta(6)-p-cymene)(mu-Cl)Cl](2) and (2S)-2-[benzyl(2-{benzyl[(2S)-1-[(diphenylphosphanyl)oxy]-3-phenyl propan-2-yl]amino}ethyl)amino]-3-phenylpropyl diphenylphosphinite or (2R)-2-[benzyl(2-{benzyl[(2R)-1-[(diphenylphosphanyl) oxy]-3-phenylpropan-2-yl]amino}ethyl) amino]-3-phenylpropyl diphenylphosphinite catalytic systems, which gave enantioselectivities of up to 93% ee and 99% conversion.en_US
dc.description.sponsorshipTubitak [108T060]en_US
dc.description.sponsorshipFinancial support from Tubitak (Project number: 108T060) is gratefully acknowledged.en_US
dc.identifier.doi10.1055/s-0032-1317505
dc.identifier.endpage2784en_US
dc.identifier.issn0936-5214
dc.identifier.issn1437-2096
dc.identifier.issue19en_US
dc.identifier.scopus2-s2.0-84868494591
dc.identifier.scopusqualityQ3
dc.identifier.startpage2777en_US
dc.identifier.urihttps://doi.org/10.1055/s-0032-1317505
dc.identifier.urihttps://hdl.handle.net/11468/16530
dc.identifier.wosWOS:000311492100011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofSynlett
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhosphinitesen_US
dc.subjectEnantioselectivityen_US
dc.subjectHydrogenationen_US
dc.subjectHomogeneous Catalysisen_US
dc.subjectRutheniumen_US
dc.subjectKetonesen_US
dc.titleBis(phosphinite) with C2-Symmetric Axis; Effects on the Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation of Acetophenone Derivativesen_US
dc.titleBis(phosphinite) with C2-Symmetric Axis; Effects on the Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation of Acetophenone Derivatives
dc.typeArticleen_US

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