Heterocyclic Schiff base derivatives containing pyrazolone moiety: Synthesis, characterization, and in vitro biological studies

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dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorÇınar, Ercan
dc.contributor.authorBaşaran, Eyüp
dc.contributor.authorErdoğan, Ömer
dc.contributor.authorÇakmak, Reşit
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorÇevik, Özge
dc.date.accessioned2021-11-05T13:05:33Z
dc.date.available2021-11-05T13:05:33Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.descriptionWOS:000709844600001
dc.description.abstractIn this study, some pyrazolone-based Schiff base derivatives 2a-e (except 2a)were synthesized for the first time and structurally illuminated by some spec-troscopic techniques (1H,13C NMR, FT-IR) and elemental analysis. Allsynthesized molecules were screened for their anticancer and antioxidantactivities, as well as AChE, BChE, and tyrosinase inhibitory properties.The obtained results exhibited that compounds 1b (IC50= 9.497 Μ) and 2a(IC50= 30.49 Μ) significantly decreased the proliferation of HeLa cells. Onthe other hand, the apoptotic effects of these two compounds were investigatedwith acridine orange/propidium iodide double staining. The apoptotic cellratios of the molecules treated with these two compounds were determined as60 and 64%. Compound 2b (IC50= 17.95 ± 0.47 Μ ) was determined to be avery active substance in the ABTS assay. Compound 2e (A0.5= 43.75± 0.62 M) indicated the closest antioxidant activity to the standard compoundα-TOC (A0.5= 50.58 ± 0.39 M) in the cupric reducing antioxidant capacity(CUPRAC) assay. In inhibition studies of enzymes, it was determined thatcompound 2c had a very active molecule in AChE, BChE, and tyrosinaseinhibitory activities with 82.79 ± 1.03, 91.39 ± 1.06, and 92.60 ± 1.80% inhibi-tion, respectively. It was determined that the target molecules 2a-e showedbetter antioxidant and enzyme inhibitory activities than those of ester deriva-tives 1a-e.en_US
dc.identifier.citationÇınar, E., Başaran, E., Erdoğan, Ö., Çakmak, R., Boğa, M. ve Çevik, Ö. (2021). Heterocyclic Schiff base derivatives containing pyrazolone moiety: Synthesis, characterization, and in vitro biological studies. Journal of the Chinese Chemical Society, Early Access.en_US
dc.identifier.doi10.1002/jccs.202100357
dc.identifier.endpage2367en_US
dc.identifier.issn0009-4536
dc.identifier.issn2192-6549
dc.identifier.issue12
dc.identifier.scopus2-s2.0-85117530733
dc.identifier.scopusqualityQ2
dc.identifier.startpage2355en_US
dc.identifier.urihttps://hdl.handle.net/11468/8144
dc.identifier.volume68en_US
dc.identifier.wosWOS:000709844600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of the Chinese Chemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer activityen_US
dc.subjectAntioxidant activityen_US
dc.subjectEnzymes inhibitoryen_US
dc.subjectHeterocyclic Schiff baseen_US
dc.titleHeterocyclic Schiff base derivatives containing pyrazolone moiety: Synthesis, characterization, and in vitro biological studiesen_US
dc.titleHeterocyclic Schiff base derivatives containing pyrazolone moiety: Synthesis, characterization, and in vitro biological studies
dc.typeArticleen_US

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