EFFECTS OF HYPERBARIC OXYGEN THERAPY ON RAT NASAL MUCOSA

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dc.contributor.authorYorgancilar, Ediz
dc.contributor.authorTunik, Selcuk
dc.contributor.authorDeveci, Engin
dc.contributor.authorGun, Ramazan
dc.contributor.authorBakir, Salih
dc.contributor.authorKinis, Vefa
dc.contributor.authorAyaz, Ercan
dc.date.accessioned2024-04-24T17:27:41Z
dc.date.available2024-04-24T17:27:41Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe objective of this study was to evaluate the histopathologic effects of hyperbaric oxygen (HBO) therapy on the rat nasal mucosa. Twelve adult Sprague-Dawley rats, each weighing 180-220 g, were used as experimental animals. The rats were divided into HBO (hyperbaric oxygen) and control group. The rats in the HBO group (n = 6) were placed into a 20-liter HBO chamber (2.5 atmospheres absolute LAW, 25-26 degrees C with 100 % oxygen) for 90 min per day. The rats received hyperbaric oxygen over a period of 7 days. The rats in the control group (n = 6) were not given HBO. All animals were sacrificed at the end of the study, and nasal tissue samples were prepared. The sections were stained with Haematoxylin and Eosin (H-E), Periodic acid-Schiff (PAS) and Trichrome-Masson to observe the under a light microscope. Immunoreactivity of pseudostratified epithelial cells of the nasal mucosa was assessed with E-cadherin expression by immunohistochemical staining. There were significant differences in the average histopathological score between the groups exposed and non-exposed to HBO. In the HBO group, degenerative changes in epithelial cells were observed. The goblet cells showed expansion of their structure. Mononuclear lymphocyte infiltration, dilation of blood vessels, and hemorrhage were observed in considerable areas of connective tissue. In the immunohistochemical evaluation of E-cadherin expression, there were no significant differences between the two groups. Biotechnol. & Biotechnol. Eq. 2012, 26(6), 3394-3396en_US
dc.identifier.doi10.5504/BBEQ.2012.0080
dc.identifier.endpage3396en_US
dc.identifier.issn1310-2818
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84871819815
dc.identifier.scopusqualityQ3
dc.identifier.startpage3394en_US
dc.identifier.urihttps://doi.org/10.5504/BBEQ.2012.0080
dc.identifier.urihttps://hdl.handle.net/11468/20141
dc.identifier.volume26en_US
dc.identifier.wosWOS:000313856200011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherDiagnosis Press Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectRaten_US
dc.subjectNasal Mucosaen_US
dc.subjectE-Cadherinen_US
dc.subjectImmunohistochemistryen_US
dc.titleEFFECTS OF HYPERBARIC OXYGEN THERAPY ON RAT NASAL MUCOSAen_US
dc.titleEFFECTS OF HYPERBARIC OXYGEN THERAPY ON RAT NASAL MUCOSA
dc.typeArticleen_US

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