Adjuvant Chemoradiation for Gastric Cancer: Multicentric Study of the Anatolian Society of Medical Oncology

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dc.contributor.authorKucukoner, Mehmet
dc.contributor.authorIsikdogan, Abdurrahman
dc.contributor.authorArpaci, Erkan
dc.contributor.authorBilici, Mehmet
dc.contributor.authorUncu, Dogan
dc.contributor.authorCetin, Bulent
dc.contributor.authorDane, Faysal
dc.date.accessioned2024-04-24T17:28:03Z
dc.date.available2024-04-24T17:28:03Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground/Aims: The aims of this study were to report the clinical outcomes of adjuvant chemo-radiotherapy after curative resection in 637 patients with gastric cancer. Methodology: The retrospective analysis included 637 patients with resectable gastric cancer and stage IB-IV (MO) from 8 medical centers between 2003 and 2010. The patients were treated with 5FU-leucovorin and radiotherapy according to Schema for INT-0116. Results: Of the 637 patients, the median of overall survival (OS) was 43.7 months and relapse free survival (RFS) was 36.6 months. OS rates were 84%, 45%, 40% while RFS rates were 81%, 45% and 35% at 1, 3 and 5-years, respectively. Hematological and gastro-intestinal toxicities (grade 1-4) were observed in 35% and 36.5% of patients, respectively. In univariate analysis, according to the Lauren classification, tumor grade, T stage, N stage, type of operation (total gastrectomy or subtotal) and surgery resection margin (R0 or R1) were found as prognostic factors on RFS and OS (p<0.05). In multivariate analysis, T stage, N stage and surgical margins were found as effective factors on OS. T stage, N stage and Lauren classification were factors affecting RFS. Conclusions: Adjuvant chemo-radiotherapy after curative resection of gastric cancer was feasible, with acceptable toxicities in the Turkish population.en_US
dc.identifier.doi10.5754/hge11709
dc.identifier.endpage2347en_US
dc.identifier.issn0172-6390
dc.identifier.issue119en_US
dc.identifier.pmid22389301
dc.identifier.startpage2343en_US
dc.identifier.urihttps://doi.org/10.5754/hge11709
dc.identifier.urihttps://hdl.handle.net/11468/20305
dc.identifier.volume59en_US
dc.identifier.wosWOS:000312689200069
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherH G E Update Medical Publishing S Aen_US
dc.relation.ispartofHepato-Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdjuvant Chemoradiationen_US
dc.subjectGastricen_US
dc.subjectCanceren_US
dc.titleAdjuvant Chemoradiation for Gastric Cancer: Multicentric Study of the Anatolian Society of Medical Oncologyen_US
dc.titleAdjuvant Chemoradiation for Gastric Cancer: Multicentric Study of the Anatolian Society of Medical Oncology
dc.typeArticleen_US

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