The Effects of Hyperbaric Oxygen Therapy Against Streptomycin Ototoxicity

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dc.contributor.authorBakir, Salih
dc.contributor.authorOzbay, Musa
dc.contributor.authorKinis, Vefa
dc.contributor.authorYorgancilar, Ediz
dc.contributor.authorGun, Ramazan
dc.contributor.authorGul, Aylin
dc.contributor.authorAlabalik, Ulas
dc.date.accessioned2024-04-24T17:24:39Z
dc.date.available2024-04-24T17:24:39Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: Hyperbaric oxygen (HBO) is an important adjuvant therapy and being increasingly used in the treatment of various disorders because of having an important antioxidant activity. This experimental study was designed to determine the possible protective effect of HBO therapy on streptomycininduced ototoxicity. Material and Method: Twenty-eight adult Wistar albino rats were divided into four groups: Streptomycin (n= 7), saline (n= 7), HBO (n= 7), and streptomycin plus HBO (n= 7). The HBO administered rats were placed into a large pressure chamber and received 100% oxygene at 2.5 atmosphere absolute for 60 minutes per day in a period of seven days. Rats were tested with DPOAE (Distortion Product Otoacoustic Emissions) in the beginning and the end of study. The animals in all groups were sacrificed under general anesthesia on the seventh day. Biopsy specimens from inner ear were stored for histopathologic examination with hematoxylin and eosin (H& E) under light microscopy. Results: Outer hair cells shown by light microscopic images were mostly preserved in control and HBO group. DPOAE measurements revealed no significant differences between the beginning and the end (p> 0.05). Streptomycin and streptomycin plus HBO treated rats showed loss of hair cells and auditory functions significantly (p< 0.05). Between the groups of streptomycin and streptomycin plus HBO; there was no statistically significance according to the analysis of the histopathological scores and DPgram results (p> 0.05). Discussion: HBO has probably no harmful effect on hair cells. But it seems to be not beneficial in a streptomycin-induced cochlear damage rat model.en_US
dc.identifier.doi10.4328/JCAM.1250
dc.identifier.endpage102en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue2en_US
dc.identifier.startpage97en_US
dc.identifier.trdizinid162380
dc.identifier.urihttps://doi.org/10.4328/JCAM.1250
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/162380
dc.identifier.urihttps://hdl.handle.net/11468/19779
dc.identifier.volume5en_US
dc.identifier.wosWOS:000215560700007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAminoglycosideen_US
dc.subjectStreptomycinen_US
dc.subjectOtotoxicityen_US
dc.subjectHearing Lossen_US
dc.subjectHyperbaric Oxygenen_US
dc.titleThe Effects of Hyperbaric Oxygen Therapy Against Streptomycin Ototoxicityen_US
dc.titleThe Effects of Hyperbaric Oxygen Therapy Against Streptomycin Ototoxicity
dc.typeArticleen_US

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