Effects of Curcumin and Doxorubicin on the Viability of Neuroblastoma Cancer Cell Line

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dc.contributor.authorÜnlü, İlker
dc.contributor.authorÖzdemir, İlhan
dc.contributor.authorÖztürk, Şamil
dc.contributor.authorTuncer, M. Cudi
dc.date.accessioned2025-03-08T18:28:46Z
dc.date.available2025-03-08T18:28:46Z
dc.date.issued2024
dc.departmentDicle Üniversitesi
dc.description.abstractAim: Neuroblastoma has a very important place among childhood diseases, and despite all the methods used in treatment, it is very difficult to prevent neuroblastoma invasion. The number of studies showing that curcumin, the most active component of turmeric, is not toxic, is increasing day by day. In this study, the anticancer activities of curcumin (Cur), one of the important active compounds, were demonstrated in the Neuroblastoma cancer cell line (Na2B). Method: Neuroblastoma cell line was used in the study. To determine the IC50 doses of Dox and Cur, Na2B cells line were cultivated with an automatic pipette. MTT analysis was performed to analyze cell survival (viability). Inhibition levels in the cells were determined at 24 and 48 hours. Results: While the IC50 of Na2B cell proliferation was approximately 124.5 uM at the 48th hour in Dox-treated cells, the IC50 value of Cur at the 48th hour was found to be 224.6 uM. Conclusion: These results showed that Cur could be an alternative agent in the treatment of neuroblastoma, and its fewer side effects compared to other chemotherapeutic agents such as Dox would increase its preferability.
dc.identifier.doi10.36516/jocass.1520583
dc.identifier.endpage194
dc.identifier.issn2667-498X
dc.identifier.issue3
dc.identifier.startpage191
dc.identifier.urihttps://doi.org/10.36516/jocass.1520583
dc.identifier.urihttps://hdl.handle.net/11468/31429
dc.identifier.volume7
dc.language.isoen
dc.publisherMerthan TUNAY
dc.relation.ispartofJournal of Cukurova Anesthesia and Surgical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectNeuroblastoma
dc.subjectNa2B cell line
dc.subjectcancer
dc.subjectMTT
dc.subjectcurcumin
dc.titleEffects of Curcumin and Doxorubicin on the Viability of Neuroblastoma Cancer Cell Line
dc.typeArticle

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