Effects of Curcumin and Doxorubicin on the Viability of Neuroblastoma Cancer Cell Line
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Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Merthan TUNAY
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Neuroblastoma has a very important place among childhood diseases, and despite all the methods used in treatment, it is very difficult to prevent neuroblastoma invasion. The number of studies showing that curcumin, the most active component of turmeric, is not toxic, is increasing day by day. In this study, the anticancer activities of curcumin (Cur), one of the important active compounds, were demonstrated in the Neuroblastoma cancer cell line (Na2B). Method: Neuroblastoma cell line was used in the study. To determine the IC50 doses of Dox and Cur, Na2B cells line were cultivated with an automatic pipette. MTT analysis was performed to analyze cell survival (viability). Inhibition levels in the cells were determined at 24 and 48 hours. Results: While the IC50 of Na2B cell proliferation was approximately 124.5 uM at the 48th hour in Dox-treated cells, the IC50 value of Cur at the 48th hour was found to be 224.6 uM. Conclusion: These results showed that Cur could be an alternative agent in the treatment of neuroblastoma, and its fewer side effects compared to other chemotherapeutic agents such as Dox would increase its preferability.
Açıklama
Anahtar Kelimeler
Neuroblastoma, Na2B cell line, cancer, MTT, curcumin
Kaynak
Journal of Cukurova Anesthesia and Surgical Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
3
