Evaluation of liver fibrosis in chronic hepatitis B patients with 2D shear wave elastography with propagation map guidance: a single-centre study

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dc.contributor.authorKavak, Seyhmus
dc.contributor.authorKaya, Safak
dc.contributor.authorSenol, Ayhan
dc.contributor.authorSogutcu, Nilgun
dc.date.accessioned2024-04-24T17:14:54Z
dc.date.available2024-04-24T17:14:54Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground The aims of this study were to evaluate liver fibrosis with two-dimensional (2D) shear wave elastography (SWE) in patients with chronic hepatitis B (CHB), to compare 2D-SWE with histopathology and to determine the change in liver stiffness values after antiviral therapy. Material and methods A total of 253 patients with CHB were included in this prospective study. 2D-SWE with propagation map guidance to measure liver stiffness, fibrosis-4 index (FIB-4) and aspartate aminotransferase to platelet ratio index (APRI) scoring and additional liver biopsy were performed in patients with CHB. Liver stiffness was measured again at 24 and 48 weeks in all patients. The Spearman rank correlation test was used to analyse the correlation between variables, and receiver operating curve analysis was used to evaluate the diagnostic performance in terms of fibrosis. Results Liver stiffness measurements made with 2D-SWE demonstrated a significant positive correlation with the fibrosis stage and FIB-4 score (r(s) = 0.774 and 0.337, respectively, p < 0.001 for both). The area under the curve value for kPa for the prediction of significant fibrosis was 0.956 (95% CIs) (0.920-0.991), and the optimal cut-off value was 8.2 kPa (sensitivity: 92.7% and specificity: 78.9%); these values were 0.978 (95% CIs, 0.945-1.000) and 10.1 kPa (sensitivity: 92.9% and specificity: 96.4%) for the prediction of severe fibrosis. After antiviral treatment, a decrease in liver stiffness values measured by 2D-SWE was detected (mean kPa values at 0 and 48 weeks; 9.24 and 7.36, respectively, p < 0.001). Conclusion In conclusion, the measurement of liver stiffness with 2D-SWE has high diagnostic performance in the determination of hepatic fibrosis and can be used to evaluate the response to treatment in patients receiving antiviral therapy.en_US
dc.identifier.doi10.1186/s12880-022-00777-7
dc.identifier.issn1471-2342
dc.identifier.issue1en_US
dc.identifier.pmid35303822
dc.identifier.urihttps://doi.org/10.1186/s12880-022-00777-7
dc.identifier.urihttps://hdl.handle.net/11468/18249
dc.identifier.volume22en_US
dc.identifier.wosWOS:000770609900002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Medical Imaging
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectShear Wave Elastographyen_US
dc.subjectPropagation Mapen_US
dc.subjectLiver Fibrosisen_US
dc.subjectChronic Hepatitis Ben_US
dc.titleEvaluation of liver fibrosis in chronic hepatitis B patients with 2D shear wave elastography with propagation map guidance: a single-centre studyen_US
dc.titleEvaluation of liver fibrosis in chronic hepatitis B patients with 2D shear wave elastography with propagation map guidance: a single-centre study
dc.typeArticleen_US

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