The Correlation between Serum VEGF Levels and Known Prognostic Risk Factors in Colorectal Carcinoma

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dc.contributor.authorBestas, Remzi
dc.contributor.authorKaplan, M. Ali
dc.contributor.authorIsikdogan, Abdurrahman
dc.date.accessioned2024-04-24T17:28:03Z
dc.date.available2024-04-24T17:28:03Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground/Aims: In the present study, we analyzed serum vascular endothelial growth factor (VEGF) levels and its correlation with the other clinicopathological characteristics of patients with colorectal carcinoma (CRC). Methodology: Seventy-one patients (F/M, 29/42; Mean age +/- SD, 53.3 +/- 13.1 years) were included. The results of serum VEGF were analysed with respect to stage, gender, age, CEA, metastases and topographical tumour localization. Results: Patients with stage 3-4 disease had significantly higher values of VEGF (253.41 pg/mL +/- 302.24) than patients with stage 1-2 (49.99 pg/L +/- 100.30) (P<0.003). Patients with the primary tumour localized in the colon had no significantly higher levels of serum VEGF than patients with the primary tumour localized in the rectum (225.97 +/- 324.88 pg/mL vs. 153.76 +/- 205.66 pg/mL, respectively, P = 0.269). The VEGF expression significantly correlated with serum CEA level (P <0.01) and clinical stages of colorectal cancer (P <0.01). The VEGF expression was not correlated with patients' age (P = 0.955) and gender (P = 0.740). Conclusions: The VEGF expression significantly correlated with advanced stage, and metastases but not age, gender, and tumour localization. VEGF may play an important role in the invasion and metastasis of CRC. Therefore, VEGF could be applied as prognostic markers in CRC.en_US
dc.identifier.doi10.5754/hge12940
dc.identifier.endpage271en_US
dc.identifier.issn0172-6390
dc.identifier.issue130en_US
dc.identifier.pmid24901122
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.5754/hge12940
dc.identifier.urihttps://hdl.handle.net/11468/20308
dc.identifier.volume61en_US
dc.identifier.wosWOS:000335085400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherH G E Update Medical Publishing S Aen_US
dc.relation.ispartofHepato-Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColon Canceren_US
dc.subjectVegfen_US
dc.subjectPrognostic Factorsen_US
dc.subjectClinical Stageen_US
dc.titleThe Correlation between Serum VEGF Levels and Known Prognostic Risk Factors in Colorectal Carcinomaen_US
dc.titleThe Correlation between Serum VEGF Levels and Known Prognostic Risk Factors in Colorectal Carcinoma
dc.typeArticleen_US

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