Toll-like receptor 2 and 4 expression in the bovine corpus luteum during the different stages of the estrous cycle

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dc.contributor.authorAtli, Mehmet Osman
dc.contributor.authorKose, Mehmet
dc.contributor.authorKaya, Mehmet Salih
dc.contributor.authorAydilek, Nurettin
dc.contributor.authorGuzeloglu, Aydin
dc.contributor.authorWiltbank, Milo C.
dc.date.accessioned2024-04-24T17:18:26Z
dc.date.available2024-04-24T17:18:26Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to elucidate the presence of components of the innate immune system in the bovine corpus luteum (CL) by detecting the expression and cell-specific localization of TLR2 and TLR4 during different stages of the estrous cycle in a control study design. Bovine CL samples were collected from a local slaughterhouse and assigned to three groups as follows: developing CL (dCL; n = 6, approx. days 3-6), mature CL (mCL; n = 5, approx. days 8-12), and regressing CL (rCL; n = 5, approx. days 17-19). An upregulation of TLR2 mRNA was detected only in rCL (P < 0.05). Localization of the TLR2 protein was particularly apparent in luteal cells and a prominent immunofluorescent signal corresponding to TLR2 was detected only in rCL. TLR4 mRNA were higher in mCL and rCL compared to dCL (P < 0.05). The presence of the TLR4 protein in bovine CL was clearly detected in the luteal cells of both mCL and rCL. The results of this study suggest a role for TLRs in the development, maintenance, and regression of bovine CL. TLR signaling mediated pathway in luteal cells may involve in the regression of CL via regulation of TLR2 and TLR4.en_US
dc.description.sponsorshipDicle University Scientific Research Foundation (DUBAP) [12-VF-60]en_US
dc.description.sponsorshipThis study was supported by Dicle University Scientific Research Foundation (DUBAP) (12-VF-60 to Mehmet O. Atli).en_US
dc.identifier.doi10.21451/1984-3143-AR0001
dc.identifier.endpage1277en_US
dc.identifier.issn1806-9614
dc.identifier.issn1984-3143
dc.identifier.scopus2-s2.0-85041175942
dc.identifier.scopusqualityQ2
dc.identifier.startpage1270en_US
dc.identifier.urihttps://doi.org/10.21451/1984-3143-AR0001
dc.identifier.urihttps://hdl.handle.net/11468/18778
dc.identifier.volume14en_US
dc.identifier.wosWOS:000423795300008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherBrazilian Coll Animal Reproductionen_US
dc.relation.ispartofAnimal Reproduction
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBovineen_US
dc.subjectCorpus Luteumen_US
dc.subjectToll-Like Receptorsen_US
dc.titleToll-like receptor 2 and 4 expression in the bovine corpus luteum during the different stages of the estrous cycleen_US
dc.titleToll-like receptor 2 and 4 expression in the bovine corpus luteum during the different stages of the estrous cycle
dc.typeArticleen_US

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