Predictive factors of cardiovascular disease in patients on maintenance hemodialysis

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dc.contributor.authorDanış, Ramazan
dc.contributor.authorÖzmen, Şehmus
dc.contributor.authorAkın, Davut
dc.contributor.authorÇelik, Fatma
dc.contributor.authorYazanel, Orhan
dc.contributor.orcid0000-0003-1492-9681
dc.contributor.orcid0000-0002-9567-7940
dc.date.accessioned2024-04-24T15:59:23Z
dc.date.available2024-04-24T15:59:23Z
dc.date.issued2008
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hasalıkları Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: The purpose of this study was to identify the role of the methylenetetrahydrofolate reductase (MTHFR) gene mutation and other predictive factors of cardiovascular disease (CVD) in patients on maintenance hemodialysis. METHODS: A total of 144 patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis for at least 6 months were recruited. The mean age of patients was 44.84 +/- 16.23 years. Serum folate, vitamin B12, homocysteine (tHcy), albumin, lipids, MTHFR C677T mutation, and smoking habits were analyzed relative to the presence of CVD. RESULTS: Forty-two of the 144 patients (29.1%) had CVD. Mean age, duration of dialysis, body mass index, CRP, Kt/V, male sex, diabetes mellitus, and currently smoking were found to be significantly higher in patients with CVD than in those without CVD (p 0.05). The means of serum folate, vitamin B12, tHcy, albumin, and percentage of past smokers were not significant (p 0.05). MTHFR C677T mutation was not found to be associated with CVD risk factors. The mean differences in tHcy levels between the TT and CC and the CT and CC genotype allele groups were significant. CONCLUSION: We recommend that duration of ESRD and CRIP predictors with traditional risk factors be taken into account when examining CVD. We suggest that if patients with ESRD have normal B12 and folate levels, abnormal tHcy level and tHcy metabolism are not risk factors for CVD in patients with ESRD. We do not recommend evaluation of the MTHFR C677T mutation and tHcy level in maintenance hemodialysis patients. The discriminative ability of risk predictors in CVD found in the study present new ideas for researchers studying this subject.en_US
dc.identifier.citationDanış, R., Özmen, Ş., Akın, D., Çelik, F. ve Yazanel, O. (2008). Predictive factors of cardiovascular disease in patients on maintenance hemodialysis. Dialysis and Transplantation, 37(2), 58-66.
dc.identifier.doi10.1002/dat.20189
dc.identifier.endpage+en_US
dc.identifier.issn0090-2934
dc.identifier.issn1932-6920
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-54549092161
dc.identifier.scopusqualityN/A
dc.identifier.startpage58en_US
dc.identifier.urihttps://doi.org/10.1002/dat.20189
dc.identifier.urihttps://hdl.handle.net/11468/14029
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/dat.20189
dc.identifier.volume37en_US
dc.identifier.wosWOS:000253241700004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDanış, Ramazan
dc.institutionauthorÖzmen, Şehmus
dc.institutionauthorAkın, Davut
dc.institutionauthorÇelik, Fatma
dc.institutionauthorYazanel, Orhan
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDialysis & Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titlePredictive factors of cardiovascular disease in patients on maintenance hemodialysisen_US
dc.titlePredictive factors of cardiovascular disease in patients on maintenance hemodialysis
dc.typeArticleen_US

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