Plasma resistin and leptin levels in overweight and lean patients with rheumatoid arthritis

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dc.contributor.authorCanoruc, Naime
dc.contributor.authorKale, Ebru
dc.contributor.authorTurhanoglu, Ayse Dicle
dc.contributor.authorOzmen, Sehmus
dc.contributor.authorOgun, Ceyla
dc.contributor.authorKaplan, Abdurahman
dc.date.accessioned2024-04-24T17:21:06Z
dc.date.available2024-04-24T17:21:06Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: Adipocytokines; are now considered important players in the etiopathogenesis of numerous metabolic and inflammatory disorders. However, plasma leptin and resistin levels in rheumatoid arthritis (RA) are still unclear. We aimed to investigate the plasma levels of leptin and resistin in patients with rheumatoid arthritis and to compare them with controls. Materials and Methods: Consecutive 52 patients with RA were compared with 52 control subjects in terms of mean leptin and resistin levels. Results: Patients with RA showed considerably higher plasma levels of leptin (34.3 +/- 27.9 vs. 11.1 +/- 4.1) and resistin (4.8 +/- 0.7 vs. 4.0 +/- 1.3) than healthy controls (P < 0.0001). There was no significant difference regarding age, duration of disease, sex, CRP, and leptin and resistin levels between overweight and lean RA Subjects. Plasma leptin level was significantly correlated with ESR (Erythrocyte Sedimentation Rate) (r = 0.287, P = 0.039) and swollen and tender joint count (r = 0.563, P < 0.0001) but not with resistin in subjects with RA. Measuring the plasma leptin level may be a potential marker of disease activity in RA. Conclusions: Studies including more RA patients might be needed to define the role of leptin and resistin in RA subjects.en_US
dc.identifier.doi10.3906/sag-0801-13
dc.identifier.endpage451en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.startpage447en_US
dc.identifier.trdizinid94180
dc.identifier.urihttps://doi.org/10.3906/sag-0801-13
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/94180
dc.identifier.urihttps://hdl.handle.net/11468/19369
dc.identifier.volume39en_US
dc.identifier.wosWOS:000268554900015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectLeptinen_US
dc.subjectResistinen_US
dc.subjectBody Mass Indexen_US
dc.subjectDisease Activityen_US
dc.titlePlasma resistin and leptin levels in overweight and lean patients with rheumatoid arthritisen_US
dc.titlePlasma resistin and leptin levels in overweight and lean patients with rheumatoid arthritis
dc.typeArticleen_US

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