Effects of unilateral and bilateral epididymectomy on testes of rats

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dc.authorid155312en_US
dc.authorid35384en_US
dc.authorid11178en_US
dc.authorid0000-0002-3280-1430en_US
dc.authorid0000-0002-9988-9385en_US
dc.authorid0000-0002-1659-1189en_US
dc.contributor.authorAktaş, Ayfer
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorAkkuş, Murat
dc.date.accessioned2020-05-15T13:07:46Z
dc.date.available2020-05-15T13:07:46Z
dc.date.issued2007
dc.departmentDepartment of Histology and Embryology, Medical School, Dicle Universityen_US
dc.description.abstractIt is generally agreed that the testis is under endocrine control from the pituitary, and is influenced by physiological and paracrine factors within the organ. The aim of this study is to analyze the effect of unilateral and bilateral epididectomy on the testicular tissue growth of rats. Twenty- one male old Sprague-Dawley rats (28 days old) were used in the study. Rats were assigned into 3 equal groups. The first group was the control group, while unilateral and bilateral epididectomy was performed on the second and third groups, respectively. Twenty-one days after the epididectomy, testicular tissues from each group were taken and fixed in Bouin solution. Paraffin sections were stained with Haematoxylin and Eosin, Vangiesson, PAS-Hemalun and examined by light microscopy. Disorganization of the germinal epithelium, desquamation, degeneration and edema in interstitial tissue was seen in the testicular cross sections of the unilateral group. Arrest in spermatozoon stage in some tubules and presence of eosinophylic stained multinucler bodies were recognizable. In the bilateral group, degeneration and atrophic status in the seminiferous tubules of the bilateral group was observed preciesly, and occasional interstitial edema and perforations in the basal lamina were recognizable. In addition, vasodilatation, arrest in spermatozoa stage and multinucleated bodies in some of the seminiferous tubules lumen were observed in some testicular cross sections of this group. As a result, epididectomy causes degeneration in the germinal epithelium and hypoplasia in Leydig cells. It is concluded that epididectomy causes degeneration in the germinal epithelium, interruption of spermatogenesis, and a notable decrease in the number of Leydig cells.en_US
dc.description.abstractUnilateral ve bilateral epididymectomy’in sıçan testis gelişimi üzerindeki etkisini araştırmak amacıyla bu çalışma planlandı. Çalışmada 21 adet 4 haftalık erkek Spraque-Dawley sıçan kullanıldı. Denek hayvanları 3 eşit gruba bölündü. Birinci grup kontrol, ikinci gruba unilateral epididektomyi ve üçüncü gruba ise b,lateral epididymectomy uygulandı. Epididymectomy sonrası 21. günde her üç grubun testis dokuları alınarak Bouin solüsyonunda fikse edildi. Parafin kesitler Hematoksilen-Eozin, HematoksilenVangiesson ve PAS-Hemalun ile boyanarak ışık mikroskobunda incelendi. Unilateral grub testis kesitlerinde germinal epitel ayrışması, deskuamasyon, dejenerasyon ile interstisiel dokuda ödem görüldü. Bazı tubüllerde spermatozoon aşamasında arrest durum ve eozinofilik boyanan multinükler hücrelerin varliğı dikkat çekiciydi. Bilateral grupta ise, testis tubüllerindeki dejenerasyon ve atrofik durum ileri derecede izlenirken, yer yer intertisiel ödem ve bazal laminada perforasyon dikkat çekiciydi. Yine bu grubun bazı testis kesitlerinde vazodilatasyon, spermatozoa aşamasında arrest durum ve bazı seminifer tubül lümeninde multinükler hücreler bu grupta da izlendi. Sonuç olarak, epididektomi testis germinal epitelinde dejenerasyon ve Leydig hücrelerinde hipoplaziye neden olmaktadıren_US
dc.identifier.citationAktaş, A., Nergiz, Y. ve Akkuş, M. (2007). Effects of unilateral and bilateral epididymectomy on testes of rats. Dicle Tıp Dergisi, 34(1), 48-52.en_US
dc.identifier.endpage52en_US
dc.identifier.issn1300-2945
dc.identifier.issn1308-9889
dc.identifier.issue1en_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://hdl.handle.net/11468/5478
dc.identifier.urihttp://www.diclemedj.org/upload/sayi/54/Dicle%20Med%20J-02597.pdf
dc.identifier.urihttps://app.trdizin.gov.tr/publication/paper/detail/TnpFd01EYzM
dc.identifier.volume34en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthor0-Belirlenecek
dc.language.isoenen_US
dc.publisherDicle Üniversitesi Tıp Fakültesien_US
dc.relation.ispartofDicle Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectEpididymectomyen_US
dc.subjectTesticularen_US
dc.subjectRaten_US
dc.subjectTestisen_US
dc.titleEffects of unilateral and bilateral epididymectomy on testes of ratsen_US
dc.title.alternativeRatlarda unilateral ve bilateral epididymectomy’in testisler üzerine etkisien_US
dc.typeArticleen_US

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